STRAP Mouse Monoclonal Antibody [A7H11] — image 1 of 3

Product details

STRAP Mouse Monoclonal Antibody [A7H11]

Catalog number HA601007

Price for HA601007

Size / count 100 µL

About this product

The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein.

Specifications

Catalog number: HA601007
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: MAP activator with WD repeats antibody MAWD antibody PTWD antibody Serine-threonine kinase receptor-associated protein antibody serine/threonine kinase receptor associated protein antibody strap antibody STRAP_HUMAN antibody UNR-interacting protein antibody UNRIP antibody WD 40 repeat protein PT WD antibody WD-40 repeat protein PT-WD antibody
Abbreviation: STRAP
Swiss Prot: Q9Y3F4 Human
Cellular Locus: Cytoplasm, Nucleus.
Host: Mouse
Species Reactivity: Human
Immunogen: Recombinant protein within human STRAP aa 201-350/350.
Isotype: IgG1
Conjugation: Non-conjugated
Type: Mouse monoclonal Antibody
Applications: WB, IHC-P
Positive Control: 293T cell lysate, Jurkat cell lysate, A549 cell lysate, MCF-7 cell lysate, SH-SY5Y cell lysate, human testis tissue.
Concentration: 2 mg/mL
Dilution: WB: 1:500 ;IHC-P: 1:200
Purity: Protein G affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 38 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for STRAP Mouse Monoclonal Antibody [A7H11]?

The catalog number for STRAP Mouse Monoclonal Antibody [A7H11] is HA601007.

What sizes are available for STRAP Mouse Monoclonal Antibody [A7H11]?

STRAP Mouse Monoclonal Antibody [A7H11] is available in the following size(s): 100 µL.

Is STRAP Mouse Monoclonal Antibody [A7H11] in stock?

STRAP Mouse Monoclonal Antibody [A7H11] is currently made to order / not held in immediate stock. Contact us for lead time.

What is STRAP Mouse Monoclonal Antibody [A7H11] used for?

Can this product be used in multiplex assays?

Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.

What happens if this product doesn’t perform as expected in my experiment?

Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.

Is this product classed as hazardous or restricted for shipping?

Some products are subject to special import/export regulations, dangerous goods handling, or licensing requirements. Where this applies, it’s noted on the product page, and any required extra documents or fees will be confirmed with you before dispatch, never added without your consent.