SIN1 Mouse Monoclonal Antibody [A6G10] — image 1 of 3

Product details

SIN1 Mouse Monoclonal Antibody [A6G10]

Catalog number HA601008

Price for HA601008

Size / count 100 µL

About this product

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex.

Specifications

Catalog number: HA601008
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: MAPKAP 1 antibody MAPKAP1 antibody MEKK2 interacting protein 1 antibody MGC2745 antibody MIP 1 antibody MIP1 antibody Mitogen activated protein kinase associated protein 1 antibody Mitogen-activated protein kinase 2-associated protein 1 antibody mSIN1 antibody OTTHUMP00000064207 antibody Ras inhibitor MGC2745 antibody SAPK interacting protein 1 antibody SAPK-interacting protein 1 antibody SIN 1 antibody SIN1_HUMAN antibody SIN1b antibody SIN1g antibody Stress activated map kinase interacting protein 1 antibody Stress activated protein kinase interacting 1 antibody Stress-activated map kinase-interacting protein 1 antibody Target of rapamycin complex 2 subunit MAPKAP1 antibody TORC2 subunit MAPKAP1 antibody
Abbreviation: MAPKAP1
Swiss Prot: Q9BPZ7 Human
Cellular Locus: Nucleus, Cell membrane, Cytoplasmic vesicle.
Host: Mouse
Species Reactivity: Human
Immunogen: Recombinant protein within human SIN1 aa 350-522.
Isotype: IgG1
Conjugation: Non-conjugated
Type: Mouse monoclonal Antibody
Applications: WB, IF-Cell, IHC-P, FC
Positive Control: Hela cell lysate, A549 cell lysate, Hela, human kidney tissue, MCF-7.
Concentration: 2 mg/mL
Dilution: WB: 1:500;IF-Cell: 1:100;IHC-P: 1:600;FC: 1:500-1:1,000
Purity: Protein G affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 59 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for SIN1 Mouse Monoclonal Antibody [A6G10]?

The catalog number for SIN1 Mouse Monoclonal Antibody [A6G10] is HA601008.

What sizes are available for SIN1 Mouse Monoclonal Antibody [A6G10]?

SIN1 Mouse Monoclonal Antibody [A6G10] is available in the following size(s): 100 µL.

Is SIN1 Mouse Monoclonal Antibody [A6G10] in stock?

SIN1 Mouse Monoclonal Antibody [A6G10] is currently made to order / not held in immediate stock. Contact us for lead time.

What is SIN1 Mouse Monoclonal Antibody [A6G10] used for?

What is the recommended incubation time for this antibody?

A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.

What should I check when this product first arrives?

Inspect the package immediately for transportation damage, ice loss, leakage, or breakage. Report any issues right away with photos and your order reference; our specialists will determine whether the product is still usable or needs replacing.

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.