BRCA1 Mouse Monoclonal Antibody [A7E3]

About this product

This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

Specifications

Catalog number

HA601009

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

BRCA 1 antibody BRCA1 antibody BRCA1 DNA repair associated antibody BRCA1/BRCA2 containing complex subunit 1 antibody BRCA1/BRCA2-containing complex, subunit 1 antibody BRCA1_HUMAN antibody BRCAI antibody BRCC 1 antibody BRCC1 antibody Breast and ovarian cancer susceptibility protein 1 antibody Breast Cancer 1 antibody Breast Cancer 1 Early Onset antibody Breast cancer type 1 susceptibility protein antibody BROVCA1 antibody FANCS antibody IRIS antibody PNCA4 antibody PPP1R53 antibody Protein phosphatase 1 regulatory subunit 53 antibody PSCP antibody RING finger protein 53 antibody RNF53 antibody

Abbreviation

BRCA1

Swiss Prot

P38398 Human, P48754 Mouse, O54952 Rat

Cellular Locus

Cytoplasm, Nucleus, Chromosome.

Host

Mouse

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human BRCA1 aa 1-200 / 1,863.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

IHC-P

Positive Control

Human lymph nodes tissue, human esophagus tissue, human brain tissue, human breast tissue, human breast cancer tissue, human skin tissue, mouse brian tissue, rat brian tissue.

Concentration

2 mg/mL

Dilution

IHC-P: 1:1,000-1:5,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 208 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No