p21 Mouse Monoclonal Antibody [A8C12] — image 1 of 2

Product details

p21 Mouse Monoclonal Antibody [A8C12]

Catalog number HA601017

Price for HA601017

Size / count 100 µL

About this product

p21WAF1, also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a protein that in humans is encoded by the CDKN1A gene located on chromosome 6 (6p21.2). May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. p21 is expressed in all adult human tissues. In tumors, the expression of p21 has been studied by immunohistochemical methods in a wide range of human tumors, such as gastric carcinoma, non-small cell lung carcinoma, and thyroid carcinoma. The expression of p21 is associated with favorable prognosis in various tumors.

Specifications

Catalog number: HA601017
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: CAP20 antibody CDK-interacting protein 1 antibody CDKI antibody CDKN1 antibody Cdkn1a antibody CDN1A_HUMAN antibody CIP1 antibody Cyclin Dependent Kinase Inhibitor 1A antibody Cyclin-dependent kinase inhibitor 1 antibody Cyclin-dependent kinase inhibitor 1A (P21) antibody Cyclin-dependent kinase inhibitor 1A (p21, Cip1) antibody DNA Synthesis Inhibitor antibody MDA-6 antibody MDA6 antibody Melanoma differentiation-associated protein 6 antibody Melanoma differentiation-associated protein antibody p21 antibody P21 protein antibody p21CIP1 antibody p21Cip1/Waf1 antibody p21WAF antibody PIC1 antibody SDI1 antibody SLC12A9 antibody WAF1 antibody Wild type p53 activated fragment 1 (WAF1) antibody Wild type p53 activated fragment 1 antibody Wildtype p53-activated fragment 1 antibody
Abbreviation: p21
Swiss Prot: P38936 Human
Cellular Locus: Nucleus, Cytoplasm.
Host: Mouse
Species Reactivity: Human
Immunogen: Recombinant protein within full length of human p21.
Isotype: IgG2a
Conjugation: Non-conjugated
Type: Mouse monoclonal Antibody
Applications: IHC-P
Positive Control: Human cervical well-differentiated squamous cell carcinoma tissue, human thyroid carcinoma tissue.
Concentration: 2 mg/mL
Dilution: IHC-P: 1:400
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 18 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for p21 Mouse Monoclonal Antibody [A8C12]?

The catalog number for p21 Mouse Monoclonal Antibody [A8C12] is HA601017.

What sizes are available for p21 Mouse Monoclonal Antibody [A8C12]?

p21 Mouse Monoclonal Antibody [A8C12] is available in the following size(s): 100 µL.

Is p21 Mouse Monoclonal Antibody [A8C12] in stock?

p21 Mouse Monoclonal Antibody [A8C12] is currently made to order / not held in immediate stock. Contact us for lead time.

What is p21 Mouse Monoclonal Antibody [A8C12] used for?

What happens if this product doesn’t perform as expected in my experiment?

Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.

Is this product classed as hazardous or restricted for shipping?

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Can you help me confirm if this product is right for my specific experiment?

Yes, contact us with details of your sample type, species, and intended application, and our specialists will confirm suitability or suggest an alternative from our supplier network if this isn’t the best fit.