p21 Mouse Monoclonal Antibody [A8C11] — image 1 of 3

Product details

p21 Mouse Monoclonal Antibody [A8C11]

Catalog number HA601018

Price for HA601018

Size / count 100 µL

About this product

p21WAF1, also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a protein that in humans is encoded by the CDKN1A gene located on chromosome 6 (6p21.2). May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. p21 is expressed in all adult human tissues. In tumors, the expression of p21 has been studied by immunohistochemical methods in a wide range of human tumors, such as gastric carcinoma, non-small cell lung carcinoma, and thyroid carcinoma. The expression of p21 is associated with favorable prognosis in various tumors.

Specifications

Catalog number: HA601018
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: CAP20 antibody CDK-interacting protein 1 antibody CDKI antibody CDKN1 antibody Cdkn1a antibody CDN1A_HUMAN antibody CIP1 antibody Cyclin Dependent Kinase Inhibitor 1A antibody Cyclin-dependent kinase inhibitor 1 antibody Cyclin-dependent kinase inhibitor 1A (P21) antibody Cyclin-dependent kinase inhibitor 1A (p21, Cip1) antibody DNA Synthesis Inhibitor antibody MDA-6 antibody MDA6 antibody Melanoma differentiation-associated protein 6 antibody Melanoma differentiation-associated protein antibody p21 antibody P21 protein antibody p21CIP1 antibody p21Cip1/Waf1 antibody p21WAF antibody PIC1 antibody SDI1 antibody SLC12A9 antibody WAF1 antibody Wild type p53 activated fragment 1 (WAF1) antibody Wild type p53 activated fragment 1 antibody Wildtype p53-activated fragment 1 antibody
Abbreviation: p21
Swiss Prot: P38936 Human
Cellular Locus: Nucleus, Cytoplasm.
Host: Mouse
Species Reactivity: Human
Immunogen: Recombinant protein within full length of human p21.
Isotype: IgG2a
Conjugation: Non-conjugated
Type: Mouse monoclonal Antibody
Applications: IHC-P
Positive Control: Human cervical well-differentiated squamous cell carcinoma tissue, human thyroid carcinoma tissue, human breast carcinoma tissue.
Concentration: 2 mg/mL
Dilution: IHC-P: 1:200-1:400
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 18 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for p21 Mouse Monoclonal Antibody [A8C11]?

The catalog number for p21 Mouse Monoclonal Antibody [A8C11] is HA601018.

What sizes are available for p21 Mouse Monoclonal Antibody [A8C11]?

p21 Mouse Monoclonal Antibody [A8C11] is available in the following size(s): 100 µL.

Is p21 Mouse Monoclonal Antibody [A8C11] in stock?

p21 Mouse Monoclonal Antibody [A8C11] is currently made to order / not held in immediate stock. Contact us for lead time.

What is p21 Mouse Monoclonal Antibody [A8C11] used for?

What should I check when this product first arrives?

Inspect the package immediately for transportation damage, ice loss, leakage, or breakage. Report any issues right away with photos and your order reference; our specialists will determine whether the product is still usable or needs replacing.

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.