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![Topoisomerase II alpha Mouse Monoclonal Antibody [A3F12] — image 1 of 2](https://cdn.genprice.uk/products/992/68dd1c8a061270361ea811fd/imageurl/ha601028.webp)
Product details
Catalog number HA601028
Price for HA601028
Size / count 100 µL
DNA topoisomerase IIα is a human enzyme encoded by the TOP2A gene. Topoisomerase IIα relives topological DNA stress during transcription, condenses chromosomes, and separates chromatids. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several chemotherapy agents and a variety of mutations in this gene have been associated with the development of drug resistance.[citation needed] Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. TOP2A has been shown to interact with SMURF2, HDAC1, CDC5L, Small ubiquitin-related modifier 1 and P53.
The catalog number for Topoisomerase II alpha Mouse Monoclonal Antibody [A3F12] is HA601028.
Topoisomerase II alpha Mouse Monoclonal Antibody [A3F12] is available in the following size(s): 100 µL.
Topoisomerase II alpha Mouse Monoclonal Antibody [A3F12] is currently made to order / not held in immediate stock. Contact us for lead time.
DNA topoisomerase IIα is a human enzyme encoded by the TOP2A gene. Topoisomerase IIα relives topological DNA stress during transcription, condenses chromosomes, and separates chromatids. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass t
Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.
Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.
Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.
