Envelope Glycoprotein Mouse Monoclonal Antibody [A1-A6]

Catalog number HA601029

Price for HA601029

Size / count 100 µL

About this product

Trimeric GP1,2 complexes form the virion surface spikes and mediate the viral entry processes, with GP1 acting as the receptor-binding subunit and GP2 as the membrane fusion subunit. At later times of infection, downregulates the expression of various host cell surface molecules that are essential for immune surveillance and cell adhesion. Down-modulates several integrins including ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGAV and ITGB1. This decrease in cell adhesion molecules may lead to cell detachment, contributing to the disruption of blood vessel integrity and hemorrhages developed during infection (cytotoxicity). Interacts with host TLR4 and thereby stimulates the differentiation and activation of monocytes leading to bystander death of T-lymphocytes. Downregulates as well the function of host natural killer cells. Counteracts the antiviral effect of host BST2/tetherin that restricts release of progeny virions from infected cells. However, cooperates with VP40 and host BST2 to activate canonical NF-kappa-B pathway in a manner dependent on neddylation.

Specifications

Catalog number: HA601029
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: GP 1,2 antibody GP antibody GP1 antibody GP2 antibody GP2-delta antibody Spike glycoprotein antibody Virion spike glycoprotein antibody
Abbreviation: GP1,2 GP1 GP2 Shed GP GP1,2-delta GP
Swiss Prot: P87666 Zaire Ebola virus
Cellular Locus: Virion membrane, Host cell membrane, Secreted.
Host: Mouse
Species Reactivity: Zaire ebolavirus
Immunogen: Synthetic peptide within Zaire Ebola virus Envelope glycoprotein aa 400-450.
Isotype: IgG2b
Conjugation: Non-conjugated
Type: Mouse monoclonal Antibody
Applications: ELISA
Concentration: 2 mg/mL
Dilution: ELISA: 1:10.000
Purity: Protein G affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 74 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for Envelope Glycoprotein Mouse Monoclonal Antibody [A1-A6]?

The catalog number for Envelope Glycoprotein Mouse Monoclonal Antibody [A1-A6] is HA601029.

What sizes are available for Envelope Glycoprotein Mouse Monoclonal Antibody [A1-A6]?

Envelope Glycoprotein Mouse Monoclonal Antibody [A1-A6] is available in the following size(s): 100 µL.

Is Envelope Glycoprotein Mouse Monoclonal Antibody [A1-A6] in stock?

Envelope Glycoprotein Mouse Monoclonal Antibody [A1-A6] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Envelope Glycoprotein Mouse Monoclonal Antibody [A1-A6] used for?

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.

What is the molecular weight of the target protein?

Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.