GM-CSF Mouse Monoclonal Antibody [A6C5] — image 1 of 2

Product details

GM-CSF Mouse Monoclonal Antibody [A6C5]

Catalog number HA601033

Price for HA601033

Size / count 100 µL

About this product

Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, natural killer cells, endothelial cells and fibroblasts that functions as a cytokine. Unlike granulocyte colony-stimulating factor, which specifically promotes neutrophil proliferation and maturation, GM-CSF affects more cell types, especially macrophages and eosinophils. GM-CSF is found in high levels in joints with rheumatoid arthritis and blocking GM-CSF as a biological target may reduce the inflammation or damage. Some drugs (e.g. otilimab) are being developed to block GM-CSF. In critically ill patients GM-CSF has been trialled as a therapy for the immunosuppression of critical illness, and has shown promise restoring monocyte and neutrophil function, although the impact on patient outcomes is currently unclear and awaits larger studies. GM-CSF stimulates monocytes and macrophages to produce pro-inflammatory cytokines, including CCL17. Elevated GM-CSF has been shown to contribute to inflammation in inflammatory arthritis, osteoarthritis, colitis asthma, obesity, and COVID-19.

Specifications

Catalog number: HA601033
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: Colony stimulating factor 2 (granulocyte-macrophage) antibody Colony Stimulating Factor 2 antibody Colony stimulating factor antibody Colony-stimulating factor antibody CSF 2 antibody CSF antibody CSF2 antibody CSF2_HUMAN antibody GM-CSF antibody GMCSF antibody Granulocyte Macrophage Colony Stimulating Factor antibody Granulocyte-macrophage colony-stimulating factor antibody MGC131935 antibody MGC138897 antibody MGI1GM antibody Molgramostin antibody Pluripoietin-a antibody Sargramostim antibody
Abbreviation: CSF2
Swiss Prot: P04141 Human
Cellular Locus: Secreted.
Host: Mouse
Species Reactivity: Human
Immunogen: Recombinant protein within Human GM-CSF aa 1-144/144.
Isotype: IgG1
Conjugation: Non-conjugated
Type: Mouse monoclonal Antibody
Applications: WB, ELISA
Concentration: 2 mg/mL
Dilution: WB: 1:2,000 ;ELISA: 1:30,000
Purity: Protein G affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 16 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for GM-CSF Mouse Monoclonal Antibody [A6C5]?

The catalog number for GM-CSF Mouse Monoclonal Antibody [A6C5] is HA601033.

What sizes are available for GM-CSF Mouse Monoclonal Antibody [A6C5]?

GM-CSF Mouse Monoclonal Antibody [A6C5] is available in the following size(s): 100 µL.

Is GM-CSF Mouse Monoclonal Antibody [A6C5] in stock?

GM-CSF Mouse Monoclonal Antibody [A6C5] is currently made to order / not held in immediate stock. Contact us for lead time.

What is GM-CSF Mouse Monoclonal Antibody [A6C5] used for?

What applications has this product been validated for?

Validated applications such as WB, ELISA, IHC, ICC, or FC are listed on the product datasheet. If you need application-specific validation data before ordering, contact our technical support team with the catalogue number.

How do I reconstitute this lyophilized product?

Reconstitution instructions, including the recommended diluent and final concentration, are provided on the datasheet. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles.

What is the recommended incubation time for this antibody?

A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.