TBK1 Mouse Monoclonal Antibody [A8D9]

Catalog number HA601045

Price for HA601045

Size / count 100 µL

About this product

TBK1 (TANK-binding kinase 1) is an enzyme with kinase activity. Specifically, it is a serine / threonine protein kinase. It is encoded by the TBK1 gene in humans. This kinase is mainly known for its role in innate immunity antiviral response. However, TBK1 also regulates cell proliferation, apoptosis, autophagy, and anti-tumor immunity. Insufficient regulation of TBK1 activity leads to autoimmune, neurodegenerative diseases or tumorigenesis. TBK1 is involved in many signaling pathways and forms a node between them. For this reason, regulation of its involvement in individual signaling pathways is necessary. This is provided by adaptor proteins that interact with the dimerization domain of TBK1 to determine its location and access to substrates. Binding to TANK leads to localization to the perinuclear region and phosphorylation of substrates which is required for subsequent production of type I interferons (IFN-I). In contrast, binding to NAP1 and SINTBAD leads to localization in the cytoplasm and involvement in autophagy. Another adaptor protein that determines the location of TBK1 is TAPE. TAPE targets TBK1 to endolysosomes.

Specifications

Catalog number: HA601045
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: EC 2.7.11.1 antibody FLJ11330 antibody FTDALS4 antibody NAK antibody NF kappa B activating kinase antibody NF kB activating kinase antibody NF-kappa-B-activating kinase antibody Serine/threonine protein kinase TBK 1 antibody Serine/threonine protein kinase TBK1 antibody Serine/threonine-protein kinase TBK1 antibody T2K antibody TANK binding kinase 1 antibody TANK-binding kinase 1 antibody TBK 1 antibody Tbk1 antibody TBK1_HUMAN antibody
Abbreviation: TBK1
Swiss Prot: Q9UHD2 Human, Q9WUN2 Mouse, D4A7D3 Rat
Cellular Locus: Cytoplasm.
Host: Mouse
Species Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein within human TBK1 aa 530-729/729.
Isotype: IgG1
Conjugation: Non-conjugated
Type: Mouse monoclonal Antibody
Applications: WB
Positive Control: K562 cell lysate, NIH/3T3 cell lysate, Hela cell lysate, MCF-7 cell lysate, HepG2 cell lysate, mouse brain tissue lysate, rat brain tissue lysate, rat stomach tissue lysate.
Concentration: 2 mg/mL
Dilution: WB: 1:2,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 84 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for TBK1 Mouse Monoclonal Antibody [A8D9]?

The catalog number for TBK1 Mouse Monoclonal Antibody [A8D9] is HA601045.

What sizes are available for TBK1 Mouse Monoclonal Antibody [A8D9]?

TBK1 Mouse Monoclonal Antibody [A8D9] is available in the following size(s): 100 µL.

Is TBK1 Mouse Monoclonal Antibody [A8D9] in stock?

TBK1 Mouse Monoclonal Antibody [A8D9] is currently made to order / not held in immediate stock. Contact us for lead time.

What is TBK1 Mouse Monoclonal Antibody [A8D9] used for?

What expression system was used for this recombinant protein?

The expression system, such as E. coli, HEK293, or insect cells, is listed on the datasheet under production details, which can affect post-translational modifications relevant to your application.

Can I return this product if I ordered the wrong one?

As a consumer, you have a 14-day right of withdrawal from receipt under EU consumer protection law, submitted via our withdrawal/cancellation request form. Note this applies to unused, undamaged products, and doesn’t override the expiry/storage conditions on performance-based claims.

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.