GNAS Mouse Monoclonal Antibody [A8F12]

About this product

This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.

Specifications

Catalog number

HA601074

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Adenylate cyclase stimulating G alpha protein antibody AHO antibody Alternative gene product encoded by XL exon antibody C20orf45 antibody dJ309F20.1.1 antibody dJ806M20.3.3 antibody Extra large alphas protein antibody GNAS antibody GNAS complex locus antibody GNAS1 antibody GPSA antibody Gs alpha subunit antibody GSA antibody GSP antibody Guanine nucleotide binding protein (G protein) alpha stimulating activity polypeptide 1 antibody Guanine nucleotide binding protein alpha stimulating activity polypeptide 1 antibody Guanine nucleotide binding protein G (s) subunit alpha isoforms short antibody Guanine nucleotide binding protein G (s) subunit alpha isoforms XLas antibody Guanine nucleotide regulatory protein antibody MGC33735 antibody NESP antibody NESP55 antibody Neuroendocrine secretory protein antibody PHP1A antibody PHP1B antibody PHP1C antibody POH antibody Protein ALEX antibody Protein GNAS antibody Protein NESP55 antibody SCG6 antibody Secretogranin VI antibody XLalphas antibody XLas antibody

Abbreviation

Guanine nucleotide-binding protein G (s) subunit alpha isoforms short Adenylate cyclase-stimulating G alpha protein GNAS GNAS1 GSP

Swiss Prot

P63092 Human, P84996 Human, Q5JWF2 Human, P63094 Mouse, Q6R0H7 Mouse, P63095 Rat, Q63803 Rat

Cellular Locus

Cell membrane.

Host

Mouse

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human GNAS aa 2-251.

Isotype

IgG2a

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IHC-P, IF-Cell

Positive Control

HepG2 cell lysate, NIH/3T3 cell lysate, human brain tissue lysate, rat pancreas tissue, human pancreas tissue, MCF-7, human breast carcinoma tissue.

Concentration

1.19 mg/mL

Dilution

WB: 1:1,000;IHC-P: 1:200-1:500;IF-Cell: 1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 46 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No