FAM38A/PIEZO1 Recombinant Mouse Monoclonal Antibody [2-10-R-A]

Catalog number HA601100

Discontinued

Price for HA601100

Size / count 100 µL

This variant is discontinued and cannot be added to your cart.

About this product

Piezo1 is a mechanosensitive ion channel protein that in humans is encoded by the gene PIEZO1. Piezo1 and its close homolog Piezo2 were cloned in 2010, using an siRNA-based screen for mechanosensitive ion channels. PIEZO1 (this gene) and PIEZO2 share 47% identity with each other and they have no similarity to any other protein and contain no known protein domains. They are predicted to have 24-36 transmembrane domains, depending on the prediction algorithm used. Piezo1 is expressed in the lungs, bladder and skin, where mechanosensation has important biological roles. Unlike Piezo2 which is highly expressed in sensory dorsal root ganglia, piezo1 is not expressed in sensory neurons. Piezo1 is also found in red blood cells, and gain of function mutations in the channels are associated with hereditary xerocytosis or stomatocytosis. Piezo1 channels are pivotal integrators in vascular biology. An allele of Piezo1, E756del, results in a gain-of-function mutation, resulting in dehydrated RBCs and conveying resistance to Plasmodium. This allele has been demonstrated in vitro to prevent cerebral malaria infection. Piezo1 has been implicated in extrusion of epidermal cells when a layer becomes too confluent to preserve normal skin homeostasis. This acts to prevent excess proliferation of skin tissue, and has been implicated in cancer biology as a contributing factor to metastases by assisting living cells in escaping from a monolayer.

Specifications

Catalog number: HA601100
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: Yes
CAS Number: 9000-83-3
Product Name Alternative: DHS Fam38a Family with sequence similarity 38 member A KIAA0233 Membrane protein induced by beta-amyloid treatment Mib PIEZ1_HUMAN Piezo-type mechanosensitive ion channel component 1 PIEZO1 Protein FAM38A Protein FAM38B Protein PIEZO1
Abbreviation: Mib, PIEZO1, FAM38A, KIAA0233
Swiss Prot: Q92508 Human, E2JF22 Mouse, Q0KL00 Rat
Cellular Locus: Endoplasmic reticulum membrane. Cell membrane.
Host: Mouse
Species Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein within Human Protein FAM38A aa 1275-1540 / 2521.
Isotype: IgG2a
Conjugation: Non-conjugated
Type: Recombinant Mouse monoclonal Antibody
Applications: WB, IHC-P, IF-Cell
Positive Control: Recombinant protein lysates, rat brain tissue, mouse hippocampus tissue, mouse brain tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:500 ;IHC-P: 1:200-1:1,000 ;IF-Cell: 1:200
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 287 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for FAM38A/PIEZO1 Recombinant Mouse Monoclonal Antibody [2-10-R-A]?

The catalog number for FAM38A/PIEZO1 Recombinant Mouse Monoclonal Antibody [2-10-R-A] is HA601100.

Is FAM38A/PIEZO1 Recombinant Mouse Monoclonal Antibody [2-10-R-A] in stock?

FAM38A/PIEZO1 Recombinant Mouse Monoclonal Antibody [2-10-R-A] is currently made to order / not held in immediate stock. Contact us for lead time.

What is FAM38A/PIEZO1 Recombinant Mouse Monoclonal Antibody [2-10-R-A] used for?

What should I check when this product first arrives?

Inspect the package immediately for transportation damage, ice loss, leakage, or breakage. Report any issues right away with photos and your order reference; our specialists will determine whether the product is still usable or needs replacing.

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.