ACSL1 Mouse Monoclonal Antibody [A9B5]

About this product

Long-chain-fatty-acid—CoA ligase 1 is an enzyme that in humans is encoded by the ACSL1 gene. The ACSL1 gene is located on the 4th chromosome, with its specific location being 4q35.1. The gene contains 28 exons. The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. In melanocytic cells ACSL1 gene expression may be regulated by MITF. ACSL1 is known to be involved in fatty-acid metabolism critical for heart function and nonspecific mental retardation. Since the ACSL4 gene is highly expressed in brain, where it encodes a brain specific isoform, an ASCL1 mutation may be an efficient diagnostic tool in mentally retarded males.

Specifications

Catalog number

HA601112

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

ACS 1 antibody ACS1 antibody ACSL 1 antibody ACSL1 antibody ACSL1_HUMAN antibody Acyl CoA synthetase 1 antibody Acyl CoA synthetase long chain family member 1 antibody Acyl-CoA synthetase 1 antibody FACL 1 antibody FACL 2 antibody FACL1 antibody FACL2 antibody Fatty acid Coenzyme A ligase long chain 1 antibody Fatty acid Coenzyme A ligase long chain 2 antibody LACS 1 antibody LACS 2 antibody LACS antibody LACS1 antibody LACS2 antibody Lignoceroyl CoA synthase antibody Long chain acyl CoA synthetase 1 antibody Long chain acyl CoA synthetase 2 antibody Long chain fatty acid CoA ligase 1 antibody Long chain fatty acid CoA ligase 2 antibody Long chain fatty acid coenzyme A ligase 1 antibody Long-chain acyl-CoA synthetase 1 antibody Long-chain acyl-CoA synthetase 2 antibody Long-chain fatty acid-CoA ligase 2 antibody Long-chain-fatty-acid--CoA ligase 1 antibody Palmitoyl CoA ligase 1 antibody Palmitoyl CoA ligase 2 antibody Palmitoyl-CoA ligase 1 antibody Palmitoyl-CoA ligase 2 antibody Paltimoyl CoA ligase 1 antibody

Abbreviation

ACSL1, FACL1, FACL2, LACS, LACS1, LACS2

Swiss Prot

P33121 Human, P41216 Mouse, P18163 Rat

Cellular Locus

Mitochondrion outer membrane, Peroxisome membrane, Microsome membrane, Endoplasmic reticulum membrane.

Host

Mouse

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human aa 151-350 / 698.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IHC-P

Positive Control

Rat kidney tissue, human liver tissue, mouse heart tissue, Raji cell lysate, HepG2 cell lysate, LO2 cell lysate, A431 cell lysate.

Concentration

2 mg/mL

Dilution

WB: 1:1,000-1:5,000 ;IHC-P: 1:200-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 78 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No