CD57 Recombinant Mouse Monoclonal Antibody [PD00-21]

About this product

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 (B3GAT1) is an enzyme that in humans is encoded by the B3GAT1 gene, whose enzymatic activity creates the CD57 epitope on other cell surface proteins. In immunology, the CD57 antigen (CD stands for cluster of differentiation) is also known as HNK1 (human natural killer-1) or LEU7. It is expressed as a carbohydrate epitope that contains a sulfoglucuronyl residue in several adhesion molecules of the nervous system. The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized. In anatomical pathology, CD57 (immunostaining) is similar to CD56 for use in differentiating neuroendocrine tumors from others. There is an increase in the number of circulating CD57 positive cells in the blood of patients who have recently undergone organ or tissue transplants, especially of the bone marrow, and in patients with HIV.

Specifications

Catalog number

HA601114

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

3-glucuronyltransferase 1 antibody 3-glucuronyltransferase antibody B3GA1_HUMAN antibody B3gat1 antibody Beta 1 3 glucuronyltransferase 1 antibody Beta-1 antibody Beta-1,3-glucuronyltransferase 1 antibody CD 57 antibody CD57 antibody CD57 antigen antibody Galactosylgalactosylxylosylprotein 3 beta glucuronosyltransferase 1 antibody Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 antibody GlcAT P antibody GlcAT-P antibody GLCATP antibody GlcUAT P antibody GlcUAT-P antibody GlcUATP antibody Glucuronosyltransferase P antibody HNK 1 antibody HNK1 antibody LEU 7 antibody LEU7 antibody LEU7 antigen antibody NK 1 antibody NK1 antibody UDP GlcUA glycoprotein beta 1 3 glucuronyltransferase antibody UDP-GlcUA:glycoprotein beta-1 antibody

Abbreviation

GlcAT-P, GlcUAT-P, B3GAT1, GLCATP,Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1,glycoprotein beta-1,3-glucuronyltransferase,Glucuronosyltransferase P,Beta-1,3-glucuronyltransferase 1

Cellular Locus

Golgi apparatus membrane, Secreted, Endoplasmic reticulum membrane.

Host

Mouse

Species Reactivity

Human

Immunogen

Synthetic peptide.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Recombinant Mouse monoclonal Antibody

Applications

IHC-P, mIHC

Positive Control

Human cervical cancer, Human non-small cell lung cancer, human Hodgkin's lymphoma tissue, human tonsil tissue.

Concentration

1 mg/mL

Dilution

IHC-P: 1:50-1:200 ;mIHC: 1:500-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 38 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes