HLA DMB Recombinant Rabbit Monoclonal Antibody [JE58-74]

About this product

HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.

Specifications

Catalog number

HA720038

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

class II antigen HLA-DM beta chain antibody class II histocompatibility antigen antibody Class II histocompatibility antigen M beta chain antibody D6S221E antibody DMB antibody HLA class II histocompatibility antigen DM beta chain antibody HLA-DM histocompatibility type, beta chain antibody M beta chain antibody Major histocompatibility complex class II DM beta antibody MHC class II antigen DMB antibody MHC class II antigen HLA DM beta chain antibody MHC class II HLA DMB antibody OTTHUMP00000029257 antibody Really interesting new gene 7 protein antibody RING 7 antibody RING7 antibody

Abbreviation

HLA-DMB

Swiss Prot

P28068 Human

Cellular Locus

Late endosome membrane, Lysosome membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within human HLA DMB aa 1-100/263.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, FC

Positive Control

Raji cell lysate, Daudi cell lysate, PANC-1, Daudi.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:5,000;IF-Cell: 1:50-1:200;IF-Tissue: 1:50-1:200;FC: 1:500-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 29 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes