CTNNBIP1 Recombinant Rabbit Monoclonal Antibody [JE58-47] — image 1 of 3

Product details

CTNNBIP1 Recombinant Rabbit Monoclonal Antibody [JE58-47]

Catalog number HA720041

Price for HA720041

Size / count 100 µL

About this product

The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. ICAT interacts directly with β-catenin and interferes with the Wnt signaling pathway. Specifically, ICAT prevents the interaction of β-catenin with TCF-4 and inhibits β-catenin--TCF-4-mediated transactivation. The negative regulatory effect of ICAT on the Wnt signaling pathway appears to inhibit tumor cell proliferation. ICAT also induces G2 arrest followed by cell death in colorectal tumor cells. The ectopic induction of ICAT inhibits the expression of β3 Tubulin and thus neuronal differentiation in embryonal carcinoma P19 cells. Structural characteristics of ICAT include a three-helix bundle and a C-terminal tail. The gene encoding human ICAT maps to chromosome 1p36.22.

Specifications

Catalog number: HA720041
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: Beta catenin interacting protein 1 antibody Beta catenin interacting protein ICAT antibody Beta-catenin-interacting protein 1 antibody Catenin beta interacting protein 1 antibody CNBP1_HUMAN antibody CTNNBIP 1 antibody CTNNBIP1 antibody ICAT antibody Inhibitor of beta catenin and Tcf 4 antibody Inhibitor of beta-catenin and Tcf-4 antibody MGC15093 antibody
Abbreviation: CTNNBIP1
Swiss Prot: Q9NSA3 Human
Cellular Locus: Nucleus, Cytoplasm.
Host: Rabbit
Species Reactivity: Human
Immunogen: Synthetic peptide within human CTNNBIP1 aa 1-50/81.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IHC-P, FC
Positive Control: HepG2 cell lysates, human skin tissue, human Colon cancer tissue, HepG2.
Concentration: 1 mg/mL
Dilution: WB: 1:500 ;IHC-P: 1:50-1:200 ;FC: 1:500-1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 9 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

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