Elp3 Recombinant Rabbit Monoclonal Antibody [JE60-10]

About this product

Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine (34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase. Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. Required for acetylation of GJA1 in the developing cerebral cortex (By similarity).

Specifications

Catalog number

HA720046

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

DKFZp761L098 antibody Elongation protein 3 homolog (S. cerevisiae) antibody Elongation protein 3 homolog antibody ELONGATION PROTEIN 3, S. CEREVISIAE, HOMOLOG OF antibody elongator acetyltransferase complex subunit 3 antibody Elongator complex protein 3 antibody elp3 antibody ELP3_HUMAN antibody FLJ10422 antibody hELP3 antibody Hypothetical protein DKFZp761L098 antibody Kat9 antibody

Abbreviation

ELP3

Swiss Prot

Q9H9T3 Human, Q9CZX0 Mouse,

Cellular Locus

Nucleus, Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human Elp3 aa 1-547/547.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

Hela cell lysate, K562 cell lysate, Jurkat cell lysate, 293 cell lysate, mouse small intestine tissue lysate, rat colon tissue lysate, mouse colon tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

62 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes