Spermine synthase Recombinant Rabbit Monoclonal Antibody [JE61-85]

About this product

This gene encodes a protein belonging to the spermidine/spermin synthase family and catalyzes the production of spermine from spermidine. Pseudogenes of this gene are located on chromosomes 1, 5, 6 and X. Mutations in this gene cause an X-linked intellectual disability called Snyder-Robinson Syndrome (SRS). Multiple transcript variants encoding different isoforms have been found for this gene. Spermine synthase is an enzyme that converts spermidine into spermine. This enzyme catalyses the following chemical reaction. Spermine synthase is a form of polyamine that is in all eukaryotes and plays a role in a variety of biological functions in plants. Its structure consists of two identical monomers of 41 kDa with three domains each, creating a homodimer formed via dimerization. The interactions between one of the three domains, the N-terminals of the monomers, is responsible for dimerization as that is where the active site is located; the central terminal consisting of four β- strands structurally forming a lid for the third domain, the C-terminal domain.

Specifications

Catalog number

HA720065

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

MRSR antibody SMS antibody Snyder Robinson X linked mental retardation syndrome antibody Spermidine aminopropyltransferase antibody Spermine synthase antibody SPMSY antibody SpS antibody SPSY_HUMAN antibody SRS antibody

Abbreviation

SMS

Swiss Prot

P52788 Human, P97355 Mouse,

Cellular Locus

Cytosol, extracellular exosome.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within human Spermine synthase aa 100-150/366.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P

Positive Control

Hela cell lysate, Jurkat cell lysate, K562 cell lysate, rat uterus tissue lysate, mouse testis tissue lysate, human placenta tissue, human prostate tissue, Hela.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000;IF-Cell: 1:50;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

41 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes