NK-p44 Recombinant Rabbit Monoclonal Antibody [JE61-04]

About this product

Natural killer (NK) cells direct cytotoxicity against tumor or virally infected cells. NK cell-mediated cytotoxicity is stimulated by several activating receptors associated with the signaling adapter DNAX activation 12/killer cell-activating receptor-associated protein (DAP12). NKp44 is a natural cytotoxicity receptor that is is expressed on IL-2-activated human NK cells and may contribute to the increased efficiency of NK cells to mediate tumor cell lysis. NKp44 is composed of one Ig-like extracellular domain, a transmembrane segment, and a cytoplasmic domain. Prolactin up-regulates and cortisol down-regulates the surface expression of NKp44 at the transcriptional level. A cellular ligand for NKp44 (NKp44L) is expressed during HIV-1 infection and is correlated with the progression of CD4+ T cell depletion and an increase of viral load. This implicates NKp44 as a therapeutic agent that may aid in the progress towards a vaccine for HIV-1 infection.

Specifications

Catalog number

HA720070

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Activating NK receptor NKp44 antibody CD336 antibody CD336 antigen antibody dJ149M18.1 antibody LY95 antibody Lymphocyte antigen 95 (activating NK receptor; NK p44) antibody Lymphocyte antigen 95 homolog (activating NK receptor; NK p44) antibody Lymphocyte antigen 95 homolog antibody Lymphocyte antigen 95, mouse, homolog of antibody Natural cytotoxicity triggering receptor 2 antibody Natural killer cell p44 related protein antibody Natural killer cell p44-related protein antibody NCR2 antibody NCTR2_HUMAN antibody NK cell activating receptor (NKp44) antibody NK cell activating receptor antibody NK cell-activating receptor antibody NK p44 antibody NK-p44 antibody NKp44 antibody

Abbreviation

NCR2

Swiss Prot

O95944 Human,

Cellular Locus

Cell membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human NK-p44 aa 1-100/276.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

K562 cell lysate, HL-60 cell lysate, human small intestine tissue, mouse kidney tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

31 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes