IRAK-1 Recombinant Rabbit Monoclonal Antibody [JE60-03] — image 1 of 2

Product details

IRAK-1 Recombinant Rabbit Monoclonal Antibody [JE60-03]

Catalog number HA720079

Price for HA720079

Size / count 100 µL

About this product

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3.

Specifications

Catalog number: HA720079
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: AA48924 antibody Il1rak antibody Interleukin 1 receptor associated kinase 1 antibody Interleukin-1 receptor-associated kinase 1 antibody IRAK antibody IRAK-1 antibody Irak1 antibody IRAK1-S antibody IRAK1_HUMAN antibody mPLK antibody OTTHUMP00000026014 antibody OTTHUMP00000026015 antibody OTTHUMP00000026020 antibody OTTHUMP00000180621 antibody Pelle antibody Pelle homolog antibody Pelle-like protein kinase antibody Plpk antibody
Abbreviation: IRAK1
Swiss Prot: P51617 Human, Q62406 Mouse
Cellular Locus: Cytoplasm, Lipid droplet, Nucleus.
Host: Rabbit
Species Reactivity: Human, Mouse
Immunogen: Recombinant protein within human IRAK-1 aa 201-500/712.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IHC-P, IP
Positive Control: A549 cell lysate, HeLa cell lysate, human colon cancer tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:2,000 ;IHC-P: 1:100-1:200 ;IP: 1-2μg/sample
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 77 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for IRAK-1 Recombinant Rabbit Monoclonal Antibody [JE60-03]?

The catalog number for IRAK-1 Recombinant Rabbit Monoclonal Antibody [JE60-03] is HA720079.

What sizes are available for IRAK-1 Recombinant Rabbit Monoclonal Antibody [JE60-03]?

IRAK-1 Recombinant Rabbit Monoclonal Antibody [JE60-03] is available in the following size(s): 100 µL.

Is IRAK-1 Recombinant Rabbit Monoclonal Antibody [JE60-03] in stock?

IRAK-1 Recombinant Rabbit Monoclonal Antibody [JE60-03] is currently made to order / not held in immediate stock. Contact us for lead time.

What is IRAK-1 Recombinant Rabbit Monoclonal Antibody [JE60-03] used for?

What is the shelf life of this product?

Shelf life and expiration dates vary by product and are shown on the product listing and label. Products used beyond their expiration date are not eligible for performance-related returns or refunds, so please check the lot number and expiry before use.

What expression system was used for this recombinant protein?

The expression system, such as E. coli, HEK293, or insect cells, is listed on the datasheet under production details, which can affect post-translational modifications relevant to your application.

Can I return this product if I ordered the wrong one?

As a consumer, you have a 14-day right of withdrawal from receipt under EU consumer protection law, submitted via our withdrawal/cancellation request form. Note this applies to unused, undamaged products, and doesn’t override the expiry/storage conditions on performance-based claims.