NDUFAB1 Recombinant Rabbit Monoclonal Antibody [JE65-76]

About this product

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa is a protein that in humans is encoded by the NDUFAB1 gene. The NDUFAB1 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. The human NDUFAB1 gene codes for a subunit of Complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. However, NDUFAB1 is an accessory subunit of the complex that is believed not to be involved in catalysis. Initially, NADH binds to Complex I and transfers two electrons to the isoalloxazine ring of the flavin mononucleotide (FMN) prosthetic arm to form FMNH2. The electrons are transferred through a series of iron-sulfur (Fe-S) clusters in the prosthetic arm and finally to coenzyme Q10 (CoQ), which is reduced to ubiquinol (CoQH2). The flow of electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen ions out of the mitochondrial matrix. In a genome-wide association study (GWAS) meta-analysis conducted across European and African American populations, the NDUFAB1 gene and two other genes (MFAP3L and PALB2) were identified as genetic loci significantly associated with anxiety disorders (ADs). Since the comorbidity of ADs arises from their shared genetic basis, these candidate genetic loci may become therapeutic targets for AD treatments. Moreover, a study to identify small molecule drug targets for Tetralogy of Fallot (TOF), a congenital malformation of the heart, found the NDUFAB1 gene to be a major hub gene of differentially expressed genes in TOF.

Specifications

Catalog number

HA720088

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

ACP antibody ACPM_HUMAN antibody Acyl carrier protein antibody Acyl carrier protein mitochondrial antibody CI SDAP antibody CI-SDAP antibody FASN 2A antibody FASN2A antibody MGC65095 antibody Mitochondrial acyl carrier protein antibody mitochondrial antibody NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1 8kDa antibody NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1 antibody NADH ubiquinone oxidoreductase 9.6 kDa subunit antibody NADH ubiquinone oxidoreductase SDAP subunit antibody NADH-ubiquinone oxidoreductase 9.6 kDa subunit antibody NDUFAB 1 antibody ndufab1 antibody SDAP antibody

Abbreviation

NDUFAB1

Swiss Prot

O14561 Human, Q9CR21 Mouse,

Cellular Locus

Mitochondrion.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human NDUFAB1 aa 57-156/156.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

Human small intestine tissue lysates, human endometrium tissue, HepG2, human heart tissue, human kidney tissue, mouse heart tissue, mouse kidney tissue, rat heart tissue, rat kidney tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500 ;IHC-P: 1:200-1:1,000 ;FC: 1:500-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 17 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes