DDX58 Recombinant Rabbit Monoclonal Antibody [JE60-05]

Catalog number HA720090

Price for HA720090

Size / count 100 µL

About this product

Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Upon activation, associates with mitochondria antiviral signaling protein (MAVS/IPS1) that activates the IKK-related kinases TBK1 and IKBKE which in turn phosphorylate the interferon regulatory factors IRF3 and IRF7, activating transcription of antiviral immunological genes including the IFN-alpha and IFN-beta interferons.

Specifications

Catalog number: HA720090
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: Ddx58 antibody DDX58_HUMAN antibody DEAD (Asp Glu Ala Asp) box polypeptide 58 antibody DEAD (Asp Glu Ala Asp/His) box polypeptide antibody DEAD box protein 58 antibody DEAD/H (Asp Glu Ala Asp/His) box polypeptide RIG1 antibody DKFZp434J1111 antibody DKFZp686N19181 antibody FLJ13599 antibody Probable ATP dependent RNA helicase DDX58 antibody Probable ATP-dependent RNA helicase DDX58 antibody Retinoic acid inducible gene 1 protein antibody Retinoic acid-inducible gene 1 protein antibody Retinoic acid-inducible gene I protein antibody RIG I antibody Rig-1 antibody RIG-I antibody RIG1 antibody rigi antibody RLR 1 antibody RNA helicase antibody RNA helicase RIG I antibody SGMRT2 antibody
Abbreviation: DDX58
Swiss Prot: O95786 Human
Cellular Locus: Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Tight junction.
Host: Rabbit
Species Reactivity: Human
Immunogen: Recombinant protein within human DDX58 aa 250-450/925.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB
Positive Control: HUVEC cell lysates.
Concentration: 1 mg/mL
Dilution: WB: 1:500
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 107 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for DDX58 Recombinant Rabbit Monoclonal Antibody [JE60-05]?

The catalog number for DDX58 Recombinant Rabbit Monoclonal Antibody [JE60-05] is HA720090.

What sizes are available for DDX58 Recombinant Rabbit Monoclonal Antibody [JE60-05]?

DDX58 Recombinant Rabbit Monoclonal Antibody [JE60-05] is available in the following size(s): 100 µL.

Is DDX58 Recombinant Rabbit Monoclonal Antibody [JE60-05] in stock?

DDX58 Recombinant Rabbit Monoclonal Antibody [JE60-05] is currently made to order / not held in immediate stock. Contact us for lead time.

What is DDX58 Recombinant Rabbit Monoclonal Antibody [JE60-05] used for?

What is the purity of this recombinant protein?

Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.