ITPA Recombinant Rabbit Monoclonal Antibody [JE61-67]

About this product

Inosine triphosphate pyrophosphatase is an enzyme that in humans is encoded by the ITPA gene, by the rdgB gene in bacteria E.coli and the HAM1 gene in yeast S. cerevisiae. Two transcript variants encoding two different isoforms have been found for this gene. Also, at least two other transcript variants have been identified which are probably regulatory rather than protein-coding. The protein encoded by this gene hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. The enzyme possesses a multiple substrate-specificity and acts on other nucleotides including xanthosine triphosphate and deoxyxanthosine triphosphate. The encoded protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency. The enzyme ITPase dephosphorylates ribavirin triphosphate in vitro to ribavirin monophosphate, and ITPase reduced enzymatic activity present in 30 % of humans potentiates mutagenesis in hepatitis C virus.[9] Gene variants predicting reduced predicted ITPase activity have been associated with decreased risk of ribavirin-induced anemia, increased risk of thrombocytopenia, lower ribavirin concentrations, as well as a ribavirin-like reduced relapse risk following interferon-based therapy for hepatitis C virus (HCV) genotype 2 or 3 infection.

Specifications

Catalog number

HA720093

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

C20orf37 antibody dJ794I6.3 antibody HLC14-06-P antibody Inosine triphosphatase (nucleoside triphosphate pyrophosphatase) antibody Inosine triphosphatase antibody inosine triphosphatase-A antibody Inosine triphosphate pyrophosphatase antibody Inosine triphosphate pyrophosphohydrolase antibody Itpa antibody ITPA_HUMAN antibody ITPase antibody My049 antibody My049 protein antibody Non canonical purine NTP pyrophosphatase antibody Non standard purine NTP pyrophosphatase antibody NTPase antibody nucleoside triphosphate diphosphatase antibody Nucleoside triphosphate pyrophosphatase antibody OK/SW-cl.9 antibody OTTHUMP00000030094 antibody OTTHUMP00000160459 antibody Putative oncogene protein hlc14-06-p antibody

Abbreviation

ITPA

Swiss Prot

Q9BY32 Human

Cellular Locus

Cytoplasm.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within human ITPA aa 101-150/194.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

U937 cell lysate, human kidney tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 21 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes