NCAPD2 Recombinant Rabbit Monoclonal Antibody [JE62-22]

About this product

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.

Specifications

Catalog number

HA720100

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

2810406C15Rik antibody 2810465G24Rik antibody CAP-D2 antibody CAPD2 antibody CEP2 antibody CEP250 antibody Chromosome condensation-related SMC-associated protein 1 antibody Chromosome-associated protein D2 antibody CNAP1 antibody CND1 antibody Condensin antibody Condensin complex subunit 1 antibody eg7 antibody hCAP-D2 antibody hCAPD2 antibody KIAA0159 antibody mKIAA0159 antibody NCAPD2 antibody non-SMC condensin I complex, subunit D2 antibody XCAP D2 homolog antibody

Abbreviation

NCAPD2

Swiss Prot

Q15021 Human

Cellular Locus

Nucleus, Cytoplasm, Chromosome.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within human NCAPD2 aa 51-200/1,401.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P

Positive Control

Hela cell lysate, HL-60 cell lysate, SiHa cell lysate, human tonsil tissue, SiHa.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000;IF-Cell: 1:100-1:200;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 157 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes