iFluor™ 594 Conjugated Cytokeratin 8 Recombinant Rabbit Monoclonal Antibody [SU0338]

About this product

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. They have been found to be useful markers of tissue differentiation, which is directly applicable to the characterization of malignant tumors. Cytokeratin 8 expression is seen in epithelium and epithelium-derived tumors. The Cytokeratin 8 and 18 pair are normally expressed in simple epithelia, but not in stratified epithelial cells. Research indicates that squamous cell carcinomas derived from stratified epithelia show abnormal expression of Cytokeratin 8 and 18, although it is not known whether these proteins contribute to the malignant phenotype of the cells. Expression of Cytokeratin 8 and 18 in oral squamous cell carcinomas is an independent prognostic marker that indicates a poor prognosis. Cytokeratin 8 expression correlates with malignancy in leukoplakia and carcinomas of the head and neck; it is expressed in all non-small-cell lung cancers. Cytokeratin 8 has been shown to possess extracellular epitopes on tumor cells, which may represent valuable targets for therapy.

Specifications

Catalog number

HA720118F

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

CARD2 antibody Cell proliferation inducing gene 46 protein antibody Cell proliferation inducing protein 46 antibody CK 8 antibody CK-8 antibody CK8 antibody CYK8 antibody Cytokeratin 8 antibody Cytokeratin-8 antibody K2C8 antibody K2C8_HUMAN antibody K8 antibody Keratin 8 antibody Keratin antibody keratin type II cytoskeletal 8 antibody Keratin-8 antibody KRT8 antibody type II cytoskeletal 8 antibody Type-II keratin Kb8 antibody

Abbreviation

CK-8, K8, KRT8, CYK8

Swiss Prot

P05787 Human, P11679 Mouse

Cellular Locus

Nucleoplasm, Nucleus matrix, Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Synthetic peptide within Human Cytokeratin 8 aa 321-370 / 483.

Isotype

IgG

Conjugation

iFluor™ 594

Type

Recombinant Rabbit monoclonal Antibody

Applications

IF-Cell, IF-Tissue, FC

Positive Control

Human breast tissue, human liver tissue, SK-Br-3, A431.

Concentration

1 mg/mL

Dilution

IF-Cell: 1:50;IF-Tissue: 1:100-1:400;FC: 1:500-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS.

Molecular Weight

Predicted band size: 54 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes