iFluor™ 488 Conjugated Cytokeratin 8 Recombinant Rabbit Monoclonal Antibody [SU0338] — image 1 of 3

Product details

iFluor™ 488 Conjugated Cytokeratin 8 Recombinant Rabbit Monoclonal Antibody [SU0338]

Catalog number HA720132F

Price for HA720132F

Size / count 100 µL

About this product

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. They have been found to be useful markers of tissue differentiation, which is directly applicable to the characterization of malignant tumors. Cytokeratin 8 expression is seen in epithelium and epithelium-derived tumors. The Cytokeratin 8 and 18 pair are normally expressed in simple epithelia, but not in stratified epithelial cells. Research indicates that squamous cell carcinomas derived from stratified epithelia show abnormal expression of Cytokeratin 8 and 18, although it is not known whether these proteins contribute to the malignant phenotype of the cells. Expression of Cytokeratin 8 and 18 in oral squamous cell carcinomas is an independent prognostic marker that indicates a poor prognosis. Cytokeratin 8 expression correlates with malignancy in leukoplakia and carcinomas of the head and neck; it is expressed in all non-small-cell lung cancers. Cytokeratin 8 has been shown to possess extracellular epitopes on tumor cells, which may represent valuable targets for therapy.

Specifications

Catalog number: HA720132F
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: CARD2 antibody Cell proliferation inducing gene 46 protein antibody Cell proliferation inducing protein 46 antibody CK 8 antibody CK-8 antibody CK8 antibody CYK8 antibody Cytokeratin 8 antibody Cytokeratin-8 antibody K2C8 antibody K2C8_HUMAN antibody K8 antibody Keratin 8 antibody Keratin antibody keratin type II cytoskeletal 8 antibody Keratin-8 antibody KRT8 antibody type II cytoskeletal 8 antibody Type-II keratin Kb8 antibody
Abbreviation: CK-8, K8, KRT8, CYK8
Swiss Prot: P05787 Human
Cellular Locus: Nucleoplasm, Nucleus matrix, Cytoplasm.
Host: Rabbit
Species Reactivity: Human
Immunogen: Synthetic peptide within Human Cytokeratin 8 aa 321-370 / 483.
Isotype: IgG
Conjugation: iFluor™ 488
Type: Recombinant Rabbit monoclonal Antibody
Applications: IF-Tissue, IF-Cell
Positive Control: Human liver tissue, SK-Br-3, human breast tissue.
Concentration: 1 mg/mL
Dilution: IF-Tissue: 1:200;IF-Cell: 1:100
Purity: Protein A affinity purified.
Form: Liquid
Buffer: Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS.
Molecular Weight: Predicted band size: 54 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for iFluor™ 488 Conjugated Cytokeratin 8 Recombinant Rabbit Monoclonal Antibody [SU0338]?

The catalog number for iFluor™ 488 Conjugated Cytokeratin 8 Recombinant Rabbit Monoclonal Antibody [SU0338] is HA720132F.

What sizes are available for iFluor™ 488 Conjugated Cytokeratin 8 Recombinant Rabbit Monoclonal Antibody [SU0338]?

iFluor™ 488 Conjugated Cytokeratin 8 Recombinant Rabbit Monoclonal Antibody [SU0338] is available in the following size(s): 100 µL.

Is iFluor™ 488 Conjugated Cytokeratin 8 Recombinant Rabbit Monoclonal Antibody [SU0338] in stock?

iFluor™ 488 Conjugated Cytokeratin 8 Recombinant Rabbit Monoclonal Antibody [SU0338] is currently made to order / not held in immediate stock. Contact us for lead time.

What is iFluor™ 488 Conjugated Cytokeratin 8 Recombinant Rabbit Monoclonal Antibody [SU0338] used for?

Is this product animal-origin-free?

Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.

Does this product need any special customs documentation to be imported to my country?

If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.

What buffer is this product supplied in?

The formulation or storage buffer is listed on the product datasheet. If you require a carrier-free or custom formulation, contact us before ordering, as this may involve a made-to-order production timeline.