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![iFluor™ 647 Conjugated Cytokeratin 14 Recombinant Rabbit Monoclonal Antibody [SC65-06] — image 1 of 2](https://cdn.genprice.uk/products/992/68dd1c8d061270361ea82118/imageurl/ha720147f.webp)
Product details
Catalog number HA720147F
Price for HA720147F
Size / count 100 µL
Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed in pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The a-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins are useful markers of tissue differentiation and, in addition, they aid in the characterization of malignant tumors. In Bowen’s disease, the characteristic malignancy of the epidermis exhibits distinct expression patterns of Cytokeratin 14. The gene encoding human Cytokeratin 14 maps to chromosome 17q12-21. Mutations in this gene lead to epidermolysis bullosa simplex, an inheritied skin disorder characterized by skin blistering due to basal keratinocyte fragility.
The catalog number for iFluor™ 647 Conjugated Cytokeratin 14 Recombinant Rabbit Monoclonal Antibody [SC65-06] is HA720147F.
iFluor™ 647 Conjugated Cytokeratin 14 Recombinant Rabbit Monoclonal Antibody [SC65-06] is available in the following size(s): 100 µL.
iFluor™ 647 Conjugated Cytokeratin 14 Recombinant Rabbit Monoclonal Antibody [SC65-06] is currently made to order / not held in immediate stock. Contact us for lead time.
Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed in pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiat
Automation compatibility varies by kit and isn’t always listed on the datasheet. Contact our technical support team with details of your platform so we can confirm with the manufacturer.
Validated applications such as WB, ELISA, IHC, ICC, or FC are listed on the product datasheet. If you need application-specific validation data before ordering, contact our technical support team with the catalogue number.
Reconstitution instructions, including the recommended diluent and final concentration, are provided on the datasheet. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles.
