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![iFluor™ 488 Conjugated FOXO1A Recombinant Rabbit Monoclonal Antibody [SU33-01] — image 1 of 2](https://cdn.genprice.uk/products/992/68dd1c8e061270361ea8262f/imageurl/ha720161f.webp)
Product details
Catalog number HA720161F
Price for HA720161F
Size / count 100 µL
FKHR (for forkhead in rhabdomyosarcoma) and FKHRL1 are members of the forkhead family of transcription factors. Transcriptional activation of FKHR proteins is regulated by the serine/threonine kinase Akt1, which phosphorylates FKHRL1 and results in FKHRL1 associating with 14-3-3 proteins and being retained in the cytoplasm. Induction of apoptosis or withdrawal of growth factors stimulates dephosphorylation and nuclear translocation of FKHR proteins, leading to FKHR-induced gene-specific transcriptional activation. FKHR, also designated forkhead box protein O1A (FOXO1), is a ubiquitously expressed protein that shuttles between the cytoplasm and nucleus. Genetic mutations in FKHR genes, including the t (2;13) and t (1;3) translocations, are commonly found in alveolar rhabdomyosarcomas. These translocations result in the fusion of the amino terminus of Pax-3 or Pax-7, including the paired box and homeodomain DNA-binding domains, with the carboxy-terminus of FKHR, which contains a transcriptional activation domain. The Pax-3/FKHR fusion protein appears to function as an oncogenic transcription factor that enhances the activation of normal Pax-3 target genes.
The catalog number for iFluor™ 488 Conjugated FOXO1A Recombinant Rabbit Monoclonal Antibody [SU33-01] is HA720161F.
iFluor™ 488 Conjugated FOXO1A Recombinant Rabbit Monoclonal Antibody [SU33-01] is available in the following size(s): 100 µL.
iFluor™ 488 Conjugated FOXO1A Recombinant Rabbit Monoclonal Antibody [SU33-01] is currently made to order / not held in immediate stock. Contact us for lead time.
FKHR (for forkhead in rhabdomyosarcoma) and FKHRL1 are members of the forkhead family of transcription factors. Transcriptional activation of FKHR proteins is regulated by the serine/threonine kinase Akt1, which phosphorylates FKHRL1 and results in FKHRL1 associating with 14-3-3 proteins and being r
Yes, contact us with details of your sample type, species, and intended application, and our specialists will confirm suitability or suggest an alternative from our supplier network if this isn’t the best fit.
Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.
Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.
