iFluor™ 488 Conjugated Sodium Potassium ATPase Recombinant Rabbit Monoclonal Antibody [ST0533]

About this product

The sodium–potassium pump (sodium–potassium adenosine triphosphatase, also known as Na⁺/K⁺-ATPase, Na⁺/K⁺ pump, or sodium–potassium ATPase) is an enzyme (an electrogenic transmembrane ATPase) found in the membrane of all animal cells. It performs several functions in cell physiology. The Na⁺/K⁺-ATPase helps maintain resting potential, affects transport, and regulates cellular volume. It also functions as a signal transducer/integrator to regulate the MAPK pathway, reactive oxygen species (ROS), as well as intracellular calcium. In fact, all cells expend a large fraction of the ATP they produce (typically 30% and up to 70% in nerve cells) to maintain their required cytosolic Na and K concentrations. For neurons, the Na⁺/K⁺-ATPase can be responsible for up to 3/4 of the cell's energy expenditure. In many types of tissue, ATP consumption by the Na⁺/K⁺-ATPases have been related to glycolysis. This was first discovered in red blood cells (Schrier, 1966), but has later been evidenced in renal cells, smooth muscles surrounding the blood vessels,[6] and cardiac purkinje cells. Recently, glycolysis has also been shown to be of particular importance for Na⁺/K⁺-ATPases in skeletal muscles, where inhibition of glycogen breakdown (a substrate for glycolysis) leads to reduced Na⁺/K⁺-ATPase activity and lower force production.

Specifications

Catalog number

HA720174F

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

ATPase Na+/K+ transporting alpha antibody adenosinetriphosphatase antibody AT1A1_HUMAN antibody ATP1A1 antibody ATP1A4 antibody ATP1AL2 antibody ATP1B antibody ATP1B1 antibody ATPase Na+/K+ transporting alpha 1 polypeptide antibody ATPase Na+/K+ transporting alpha 4 polypeptide antibody ATPase Na+/K+ transporting beta 1 polypeptide antibody ATPase, Na+/K+ transporting, alpha polypeptide-like 2 antibody ATPase, Na+/K+ transporting, beta 1 polypeptide antibody Beta 1-subunit of Na (+),K (+)-ATPase antibody Na (+)/K (+) ATPase alpha-1 subunit antibody Na (+)/K (+) ATPase alpha-4 subunit antibody Na+, K+ ATPase alpha subunit antibody Na+/K+ ATPase 1 antibody Na+/K+ ATPase 4 antibody Na+/K+ ATPase, alpha-D polypeptide antibody Na, K-ATPase beta-1 polypeptide antibody Na, K-ATPase, alpha-A catalytic polypeptide antibody Na,K-ATPase catalytic subunit alpha-A protein antibody Na,K-ATPase subunit alpha-C antibody polypeptide-like 2 antibody Sodium pump 1 antibody sodium pump 4 antibody Sodium pump subunit alpha-1 antibody sodium pump subunit alpha-4 antibody sodium pump subunit beta-1 antibody sodium-potassium ATPase catalytic subunit alpha-1 antibody sodium-potassium ATPase catalytic subunit alpha-4 antibody sodium-potassium ATPase subunit beta 1 (non-catalytic) antibody sodium-potassium ATPase, alpha 4 polypeptide antibody sodium-potassium-ATPase, alpha 1 polypeptide antibody Sodium/potassium transporting ATPase alpha 1 chain antibody Sodium/potassium transporting ATPase subunit beta 1 antibody sodium/potassium-dependent ATPase beta-1 subunit antibody sodium/potassium-transporting ATPase alpha-4 chain antibody sodium/potassium-transporting ATPase beta-1 chain antibody Sodium/potassium-transporting ATPase subunit alpha-1 antibody sodium/potassium-transporting ATPase subunit alpha-4 antibody

Abbreviation

Na (+)/K (+) ATPase alpha-1 subunit, ATP1A1, ATP1B1, ATP1B, Na (+)/K (+) ATPase alpha-4 subunit, ATP1A4, ATP1AL2

Swiss Prot

P05023 Human, P05026 Human, Q13733 Human, P06685 Rat, P07340 Rat, Q64541 Rat

Cellular Locus

Cell membrane, Melanosome.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human ATP1A1 aa 39-83 / 1023.

Isotype

IgG

Conjugation

iFluor™ 488

Type

Recombinant Rabbit monoclonal Antibody

Applications

IF-Tissue

Positive Control

Rat kidney tissue, human liver tissue.

Concentration

1 mg/mL

Dilution

IF-Tissue: 1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS.

Molecular Weight

100 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes