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Product details

CYB5R3 Recombinant Rabbit Monoclonal Antibody [JE63-51]

Catalog number HA721008

Price for HA721008

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Size / count 100 µL

About this product

NADH-cytochrome b5 reductase 3 is an enzyme that in humans is encoded by the CYB5R3 gene. Cytochrome b5 reductase is involved in the transfer of reducing equivalents from the physiological electron donor, NADH, via an FAD domain to the small molecules of cytochrome b5. It’s also heavily involved in many oxidation and reduction reactions, such as the reduction of methemoglobin to hemoglobin.[8] Of the two forms of NADH-cytochrome b5 reductase, the membrane-bound form exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble fraction of circulating erythrocytes and is involved in methemoglobin reduction. Mutations in the CYB5R3 gene cause methemoglobinemia types I and II. This is a rare autosomal recessive disease due to a deficiency of isoform of NADH-cytochrome b5 reductase.

Specifications

Catalog number
HA721008
Size / count
100 µL
Dry ice
No
Hazardous
No
Discontinued
No
CAS Number
9000-83-3
Product Name Alternative
B5R antibody Cyb5r3 antibody Cytochrome b5 reductase 3 antibody Cytochrome b5 reductase antibody DIA1 antibody Diaphorase 1 antibody Diaphorase-1 antibody NADH cytochrome b5 reductase 3 antibody NADH-cytochrome b5 reductase 3 membrane-bound form antibody NADH-cytochrome b5 reductase 3 soluble form antibody NB5R3_HUMAN antibody OTTHUMP00000028761 antibody OTTHUMP00000198435 antibody OTTHUMP00000198574 antibody OTTHUMP00000198662 antibody OTTHUMP00000198665 antibody
Abbreviation
CYB5R3
Swiss Prot
P00387 Human, P20070 Rat
Cellular Locus
Endoplasmic reticulum membrane, Mitochondrion outer membrane; Cytoplasm.
Host
Rabbit
Species Reactivity
Human, Rat
Immunogen
Recombinant protein within human CYB5R3 aa 1-150/301.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB
Positive Control
U87MG cell lysate, 293 cell lysate, PC-12 cell lysate, rat lung tissue lysate, rat brain tissue lysate.
Concentration
1 mg/mL
Dilution
WB: 1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 34 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes

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