MEF2A + MEF2C Recombinant Rabbit Monoclonal Antibody [JE63-26]

About this product

The protein encoded by MEF2A is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene. This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe cognitive disability, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described.

Specifications

Catalog number

HA721030

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

ADCAD1 antibody MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A) antibody MEF2 antibody MEF2A antibody MEF2A_HUMAN antibody Myocyte enhancer factor 2A antibody Myocyte-specific enhancer factor 2A antibody RSRFC4 antibody RSRFC9 antibody Serum response factor like protein 1 antibody Serum response factor-like protein 1 antibody C5DELq14.3 antibody DEL5q14.3 antibody MADS box transcription enhancer factor 2 polypeptide C (myocyte enhancer factor 2C) antibody MADS box transcription enhancer factor 2, polypeptide C antibody MEF2C antibody MEF2C_HUMAN antibody Myocyte enhancer factor 2C antibody Myocyte specific enhancer factor 2C antibody Myocyte-specific enhancer factor 2C antibody OTTHUMP00000222409 antibody Similar to MADS box transcription enhancer factor 2 polypeptide C antibody

Abbreviation

MEF2A, MEF2C

Swiss Prot

Q02078 Human, Q06413 Human, Q60929 Mouse, Q8CFN5 Mouse, Q2MJT0 Rat, A0A096MJY4 Rat

Cellular Locus

Nucleus. Nucleus, sarcoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human MEF2C aa 250-473/473.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

Daudi cell lysates, rat skeletal muscle tissue, human striated muscle tissue, human glioma tissue, mouse hippocampus tissue, mouse brain tissue, Daudi.

Concentration

1 mg/mL

Dilution

WB: 1:500 ;IHC-P: 1:400 ;FC: 1:500-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 55/51 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes