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![MDH2 Recombinant Rabbit Monoclonal Antibody [JE64-68] — image 1 of 3](https://cdn.genprice.uk/products/992/68dd1c8f061270361ea827a0/imageurl/ha721043.webp)
Product details
Catalog number HA721043
Price for HA721043
Size / count 100 µL
Malate dehydrogenase, mitochondrial also known as malate dehydrogenase 2 is an enzyme that in humans is encoded by the MDH2 gene. Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Mutations in the MDH2 gene have been associated with several cancers, including uterine cancer, prostate cancer, pheochromocytoma and other paragangliomas. In particular, MDH2 has been found to be overexpressed in doxorubicin-resistant uterine cancer cells and may contribute to drug resistance. Since MDH2 plays a major role in malate-aspartate shuttling in ATP production, its overexpression likely supplies additional energy for P-glycoprotein to pump chemotherapeutic drugs out of the cells. Likewise, MDH2 contributes to docetaxel resistance in prostate cancer cells via the JNK pathway, and its knockdown reduced ATP levels as well as increased drug sensitivity. Thus, MDH2 may be an effective therapeutic target to enhance drug treatments for cancer.
The catalog number for MDH2 Recombinant Rabbit Monoclonal Antibody [JE64-68] is HA721043.
MDH2 Recombinant Rabbit Monoclonal Antibody [JE64-68] is available in the following size(s): 100 µL.
MDH2 Recombinant Rabbit Monoclonal Antibody [JE64-68] is currently made to order / not held in immediate stock. Contact us for lead time.
Malate dehydrogenase, mitochondrial also known as malate dehydrogenase 2 is an enzyme that in humans is encoded by the MDH2 gene. Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by
Immunogen or antigen details used to raise this antibody are listed on the product datasheet under immunogen information.
A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.
Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.
