AK2 Recombinant Rabbit Monoclonal Antibody [JE64-27]

About this product

Adenylate kinase 2 is an enzyme that is encoded in humans by the AK2 gene. The AK2 protein is found in the intermembrane space of the mitochondrion. Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Two transcript variants encoding distinct isoforms have been identified for this gene. Adenylate Kinase 2 (AK2) deficiency in humans causes hematopoietic defects associated with sensorineural deafness. Reticular dysgenesis is an autosomal recessive form of human combined immunodeficiency. It is also characterized by an impaired lymphoid maturation and early differentiation arrest in the myeloid lineage. AK2 deficiency results in absent or a large decrease in the expression of proteins. AK2 is specifically expressed in the stria vascularis of the inner ear which indicates why individuals with an AK2 deficiency will have sensorineural deafness.

Specifications

Catalog number

HA721048

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Adenylate kinase 2 antibody adenylate kinase 2, mitochondrial antibody Adenylate kinase isoenzyme 2 antibody ADK2 antibody AK 2 antibody ak2 antibody ATP AMP transphosphorylase antibody ATP-AMP transphosphorylase 2 antibody EC 2.7.4.3 antibody KAD2_HUMAN antibody mitochondrial antibody

Abbreviation

AK2

Swiss Prot

P54819 Human, Q9WTP6 Mouse, P29410 Rat

Cellular Locus

Mitochondrion intermembrane space.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within human AK2 aa 150-200/239.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IF-Cell

Positive Control

A549 cell lysate, HL-60 cell lysate, HepG2 cell lysate, Mouse liver cell lysate, Mouse kidney cell lysate, Rat liver cell lysate, Rat kidney cell lysate, human kidney tissue, A375 .

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:5,000 ;IHC-P: 1:100 ;IF-Cell: 1:50

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 26 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes