ACADS Recombinant Rabbit Monoclonal Antibody [JE64-13]

About this product

Acyl-CoA dehydrogenase, C-2 to C-3 short chain is an enzyme that in humans is encoded by the ACADS gene. This gene encodes a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. The ACADS gene associated with short-chain acyl-coenzyme A dehydrogenase deficiency. The SCAD enzyme catalyzes the first part of fatty acid beta-oxidation by forming a C2-C3 trans-double bond in the fatty acid through dehydrogenation of the flavoenzyme. SCAD is specific to short-chain fatty acids, between C2 and C3-acylCoA. The final result of beta-oxidation is acetyl-CoA. When there are defects that result in SCAD being misfolded, there is an increased production of reactive oxygen species (ROS); the increased ROS forces the mitochondria to undergo fission, and the mitochondrial reticulum takes on a grain-like structure. Mutations of the ACADS gene are associated with deficiency of the short-chain acyl-coenzyme A dehydrogenase protein (SCADD); this is also known as butyryl-CoA dehydrogenase deficiency. The ACADS gene has also been implicated in delaying the onset of Prader-Willi Syndrome, which is characterized by hypotonia, growth failure, and neurodevelopmental delays in the first years of life, and hyperphagia and obesity much later. In Genome Wide Association Studies (GWAS), SCAD has been associated with a reduced amount of insulin release shown by an oral glucose tolerance test, or OGTT.

Specifications

Catalog number

HA721058

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

ACAD3 antibody ACADS antibody ACADS_HUMAN antibody Acyl Coenzyme A dehydrogenase, C2 to C3 short chain antibody Acyl-CoA dehydrogenase, C2 to C3 short chain antibody Acyl-CoA dehydrogenase, short chain antibody Acyl-Coenzyme A dehydrogenase, short chain antibody AI196007 antibody Bcd-1 antibody Bcd1 antibody Butyryl CoA dehydrogenase antibody Butyryl-CoA dehydrogenase antibody EC 1.3.99.2 antibody mitochondrial antibody SCAD antibody Short chain acyl CoA dehydrogenase antibody Short-chain specific acyl-CoA dehydrogenase antibody Short-chain specific acyl-CoA dehydrogenase, mitochondrial antibody Unsaturated acyl CoA reductase antibody

Abbreviation

ACADS

Swiss Prot

P16219 Human, Q07417 Mouse, P15651 Rat

Cellular Locus

Mitochondrion matrix.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within human ACADS aa 363-412/412.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

A549 cell lysate, Mouse liver tissue lysate, Mouse kidney tissue lysate, Rat liver tissue lysate, Rat kidney tissue lysate, human liver tissue, human colon carcinoma tissue.

Concentration

1 mg/mL

Dilution

WB: 1:2,000 ;IHC-P: 1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 44 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes