CRABP2 Recombinant Rabbit Monoclonal Antibody [JE65-66]

About this product

Cellular retinoic acid-binding protein 2 is a cytoplasmic binding protein that in humans is encoded by the CRABP2 gene. CRABP2 is structurally similar to CRABP1, but CRABP2 has a lower affinity for retinoic acid (RA). CRABP2 is associated with cells that produce large amounts of retinoic acid and may play a role in mediating the effects of retinoic acid in the cell. A number of specific carrier proteins for members of the vitamin A family have been discovered. Retinoic acid is an active metabolite of vitamin A (retinol). Cellular retinoic acid binding proteins (CRABP) are low molecular weight proteins whose precise function remains largely unknown. The inducibility of the CRABP2 gene suggests that this isoform is important in retinoic acid-mediated regulation of human skin growth, differentiation and development. CRABP2 is involved in the metabolism and transportation of retinoic acid from the cytosol to the RARs (retinoic acid receptors) located in the nucleus. CRABP2 is specifically co-expressed with RAR-β and cellular retinol binding protein 1 genes in certain tissues. It has been postulated that the CRABP2 gene is transcriptionally regulated by a newly synthesized regulatory protein.

Specifications

Catalog number

HA721070

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Cellular retinoic acid binding protein 2 antibody Cellular retinoic acid binding protein II antibody Cellular retinoic acid-binding protein 2 antibody Cellular retinoic acid-binding protein II antibody CRABP II antibody CRABP-II antibody Crabp2 antibody CRABPII antibody RABP2_HUMAN antibody RBP6 antibody Rretinoic acid-binding protein, cellular, type II antibody

Abbreviation

CRABP2

Swiss Prot

P29373 Human

Cellular Locus

Endoplasmic reticulum, Nucleus, Cytoplasm.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within human CRABP2 aa 1-138/138.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

MCF-7 cell lysates, human esophagus tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IHC-P: 1:400

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 16 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes