OXGR1 Recombinant Rabbit Monoclonal Antibody [JE64-04]

About this product

2-Oxoglutarate receptor 1 (OXGR1), also known as cysteinyl leukotriene receptor E (CysLTE) and GPR99, is a protein that in humans is encoded by the OXGR1 (also termed GPR99) gene. The Gene has recently been nominated as a receptor not only for 2-oxogluterate (see alpha-Ketoglutaric acid) but also for the three cysteinyl leukotrienes (CysLTs), particularly leukotriene E4 (LTE4) and to far lesser extents LTC4 and LTE4. Recent studies implicate GPR99 as a cellular receptor which is activated by LTE4 thereby causing these cells to contribute to mediating various allergic and hypersensitivity responses. Montelucast is in use to treat various conditions including asthma, exercise-induced bronchoconstriction, allergic rhinitis, primary dysmenorrhoea (i.e. dysmenorrhoea not associated with known causes; see dysmenorrhea#Causes), and urticaria. It has been presumed that this drug's beneficial effects in these diseases is due to its well-known ability to act as a receptor antagonist for the cysteinyl leukotriene receptor 1, i.e. it binds to but does not activate this receptor thereby interfering with LTD4, LTC4, and LTE4 provocative actions by blocking their binding to CysLTR1.

Specifications

Catalog number

HA721074

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

2 oxoglutarate receptor 1 antibody 2-oxoglutarate receptor 1 antibody aKGR antibody Alpha ketoglutarate receptor 1 antibody Alpha-ketoglutarate receptor 1 antibody G Protein Coupled Receptor 80 antibody G Protein Coupled Receptor 99 antibody G-protein coupled receptor 80 antibody G-protein coupled receptor 99 antibody GPR80 antibody GPR99 antibody MGC119206 antibody MGC119207 antibody MGC119208 antibody OXGR 1 antibody Oxgr1 antibody OXGR1_HUMAN antibody Oxoglutarate (alpha ketoglutarate) receptor 1 antibody Oxoglutarate receptor 1 antibody P2RY15 antibody P2Y like GPCR antibody P2Y like nucleotide receptor antibody P2Y purinoceptor 15 antibody P2Y-like GPCR antibody P2Y-like nucleotide receptor antibody P2Y15 antibody

Abbreviation

OXGR1

Swiss Prot

Q96P68 Human, Q6IYF8 Mouse, Q6Y1R5 Rat

Cellular Locus

Cell membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within human OXGR1 aa 171-220/337.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB

Positive Control

Hela cell lysate, rat brain tissue lysate, mouse testis tissue lysates, rat testis tissue lysates.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 38 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes