Homer1 Recombinant Rabbit Monoclonal Antibody [JE65-19]

Catalog number HA721081

Price for HA721081

Size / count 100 µL

About this product

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA.

Specifications

Catalog number: HA721081
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: HOME1_HUMAN antibody Homer antibody HOMER 1A antibody HOMER 1B antibody HOMER 1C antibody Homer homolog 1 (Drosophila) antibody homer homolog 1 antibody Homer protein homolog 1 antibody homer scaffolding protein 1 antibody Homer, Drosophila, homolog of, 1 antibody Homer, neuronal immediate early gene, 1 antibody Homer-1 antibody Homer1 antibody HOMER1A antibody HOMER1B antibody HOMER1C antibody SYN47 antibody Ves 1 antibody
Abbreviation: HOMER1
Swiss Prot: Q9Z2Y3 Mouse, Q9Z214 Rat
Cellular Locus: Cytoplasm, postsynaptic density, synapse, dendritic spine.
Host: Rabbit
Species Reactivity: Mouse, Rat
Immunogen: Recombinant protein within human Homer1 aa 101-250/354.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IHC-P, IHC-Fr
Positive Control: Rat brain tissue lysate, Mouse brain tissue lysate, mouse brain tissue, mouse hippocampus tissue, rat cerebellum tissue, rat brain tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000 ;IHC-P: 1:400 ;IHC-Fr: 1:200
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 40 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Homer1 Recombinant Rabbit Monoclonal Antibody [JE65-19]?

The catalog number for Homer1 Recombinant Rabbit Monoclonal Antibody [JE65-19] is HA721081.

What sizes are available for Homer1 Recombinant Rabbit Monoclonal Antibody [JE65-19]?

Homer1 Recombinant Rabbit Monoclonal Antibody [JE65-19] is available in the following size(s): 100 µL.

Is Homer1 Recombinant Rabbit Monoclonal Antibody [JE65-19] in stock?

Homer1 Recombinant Rabbit Monoclonal Antibody [JE65-19] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Homer1 Recombinant Rabbit Monoclonal Antibody [JE65-19] used for?

Is there an additional fee for hazardous or dry ice shipping of this product?

Yes, if this product requires dry ice or is classed as hazardous for transport, the additional fee will be explicitly shown in your quotation before you confirm the order, so there are no surprise charges later.

How many freeze-thaw cycles can this product tolerate?

We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.