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![PRPF31 Recombinant Rabbit Monoclonal Antibody [JE64-82] — image 1 of 3](https://cdn.genprice.uk/products/992/68dd1c8a061270361ea80eff/imageurl/ha721089.webp)
Product details
Catalog number HA721089
Price for HA721089
Size / count 100 µL
PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae), also known as PRPF31, is a protein which in humans is encoded by the PRPF31 gene. PRPF31 is the gene coding for the splicing factor hPRP31. It is essential for the formation of the spliceosome hPRP31 is associated with the U4/U6 di-snRNP and interacts with another splicing factor, hPRP6, to form the U4/U6-U5 tri-snRNP. It has been shown that when hPRP31 is knocked down by RNAi, U4/U6 di-snRNPs accumulate in the Cajal bodies and the U4/U6-U5 tri-snRNP cannot form. PRPF31 is recruited to introns following the attachment of U4 and U6 RNAs and the 15.5K protein NHP2L1. The addition of PRPF31 is crucial for the transition of the spliceosomal complex to the activated state. A mutation in PRPF31 is one of 4 known mutations in splicing factors which are known to cause retinitis pigmentosa. The first mutation in PRPF31 was discovered by Vithana et al. in 2001. Retinitis pigmentosa (RP) is a clinically and genetically heterogeneous group of retinal dystrophies characterized by a progressive degeneration of photoreceptors, eventually resulting in severe visual impairment.
The catalog number for PRPF31 Recombinant Rabbit Monoclonal Antibody [JE64-82] is HA721089.
PRPF31 Recombinant Rabbit Monoclonal Antibody [JE64-82] is available in the following size(s): 100 µL.
PRPF31 Recombinant Rabbit Monoclonal Antibody [JE64-82] is currently made to order / not held in immediate stock. Contact us for lead time.
PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae), also known as PRPF31, is a protein which in humans is encoded by the PRPF31 gene. PRPF31 is the gene coding for the splicing factor hPRP31. It is essential for the formation of the spliceosome hPRP31 is associated with the U4/U6 di-snRNP a
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