GNE Recombinant Rabbit Monoclonal Antibody [JE64-81]

Catalog number HA721090

Price for HA721090

Size / count 100 µL

About this product

Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase is an enzyme that in humans is encoded by the GNE gene. The bifunctional enzyme, UDP-N-acetylglucosamine 2-epimerase regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. UDP-GlcNAc 2-epimerase activity is rate-limiting for the biosynthesis of sialic acid and is required for sialylation in hematopoietic cells. The activity of the enzyme can be controlled at the transcriptional level and can affect the sialylation and function of specific cell surface molecules expressed on B cells and myeloid cells. Modification of cell surface molecules with sialic acid is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Sialuria is a rare inborn error of metabolism characterized by cytoplasmic accumulation and increased urinary excretion of free NeuAc.

Specifications

Catalog number: HA721090
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: 2310066H07Rik antibody Bifunctional UDP N acetylglucosamine 2 epimerase/N acetylmannosamine kinase antibody DMRV antibody GLCNE_HUMAN antibody Glucosamine (UDP N acetyl) 2 epimerase/N acetylmannosamine kinase antibody GNE antibody IBM2 antibody ManAc kinase antibody N acylmannosamine kinase antibody N-acetylmannosamine kinase antibody NM antibody RP23-209M8.6 antibody Uae1 antibody UDP GlcNAc 2 epimerase antibody UDP GlcNAc 2 epimerase/ManAc kinase antibody UDP N acetylglucosamine 2 epimerase/N acetylmannosamine kinase antibody UDP-GlcNAc-2-epimerase antibody UDP-GlcNAc-2-epimerase/ManAc kinase antibody Uridine diphosphate N acetylglucosamine 2 epimerase antibody Uridine diphosphate-N-acetylglucosamine-2-epimerase antibody
Abbreviation: GNE
Swiss Prot: Q9Y223 Human
Cellular Locus: Cytoplasm.
Host: Rabbit
Species Reactivity: Human
Immunogen: Synthetic peptide within human GNE aa 673-722/722.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB
Positive Control: SW480 cell lysate, A549 cell lysate, Hela cell lysate.
Concentration: 1 mg/mL
Dilution: WB: 1:500
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 79 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for GNE Recombinant Rabbit Monoclonal Antibody [JE64-81]?

The catalog number for GNE Recombinant Rabbit Monoclonal Antibody [JE64-81] is HA721090.

What sizes are available for GNE Recombinant Rabbit Monoclonal Antibody [JE64-81]?

GNE Recombinant Rabbit Monoclonal Antibody [JE64-81] is available in the following size(s): 100 µL.

Is GNE Recombinant Rabbit Monoclonal Antibody [JE64-81] in stock?

GNE Recombinant Rabbit Monoclonal Antibody [JE64-81] is currently made to order / not held in immediate stock. Contact us for lead time.

What is GNE Recombinant Rabbit Monoclonal Antibody [JE64-81] used for?

What should I check when this product first arrives?

Inspect the package immediately for transportation damage, ice loss, leakage, or breakage. Report any issues right away with photos and your order reference; our specialists will determine whether the product is still usable or needs replacing.

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.