GALT Recombinant Rabbit Monoclonal Antibody [JE64-66]

About this product

Galactose-1-phosphate uridylyltransferase (or GALT, G1PUT) is an enzyme responsible for converting ingested galactose to glucose. Deficiency of GALT causes classic galactosemia. Galactosemia is an autosomal recessive inherited disorder detectable in newborns and childhood. Classical galactosemia (G/G) is caused by a deficiency in GALT activity, whereas the more common clinical manifestations, Duarte (D/D) and the Duarte/Classical variant (D/G) are caused by the attenuation of GALT activity. Symptoms include ovarian failure, developmental coordination disorder (difficulty speaking correctly and consistently), and neurologic deficits. A single mutation in any of several base pairs can lead to deficiency in GALT activity. Screening has mostly eliminated neonatal death by G/G galactosemia, but the disease, due to GALT’s role in the biochemical metabolism of ingested galactose (which is toxic when accumulated) to the energetically useful glucose, can certainly be fatal. However, those afflicted with galactosemia can live relatively normal lives by avoiding milk products and anything else containing galactose (because it cannot be metabolized), but there is still the potential for problems in neurological development or other complications, even in those who avoid galactose.

Specifications

Catalog number

HA721092

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Gal 1 P uridylyltransferase antibody Gal-1-P uridylyltransferase antibody Galactose 1 phosphate uridyl transferase antibody Galactose 1 phosphate uridylyltransferase antibody Galactose-1-phosphate uridylyltransferase antibody GALT antibody GALT_HUMAN antibody UDP glucose hexose 1 phosphate uridylyltransferase antibody UDP-glucose--hexose-1-phosphate uridylyltransferase antibody

Abbreviation

GALT

Swiss Prot

P07902 Human, Q03249 Mouse, P43424 Rat

Cellular Locus

Cytosol, Golgi apparatus, cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within human GALT aa 41-90/379.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

Hela cell lysate, HepG2 cell lysate, rat brain tissue lysate, mouse kidney tissue lysate, rat bladder tissue, mouse large intestine tissue, human kidney tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500 ;IHC-P: 1:100-1:400

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 43 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes