PCBP2 Recombinant Rabbit Monoclonal Antibody [JE65-05]

About this product

The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly (rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

Catalog number

HA721109

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Alpha CP2 antibody Alpha-CP2 antibody alphaCP-2 antibody Cbp antibody CTBP antibody Heterogeneous nuclear ribonucleoprotein E2 antibody Heterogenous nuclear ribonucleoprotein E2 antibody hnRNP E2 antibody hnRNP-E2 antibody HNRNPE2 antibody Hnrnpx antibody HNRPE2 antibody Hnrpx antibody MGC110998 antibody PCBP2 antibody PCBP2_HUMAN antibody poly (rC) binding protein 2 antibody Poly (rC)-binding protein 2 antibody Putative heterogeneous nuclear ribonucleoprotein X antibody rCbinding protein 2 antibody

Abbreviation

PCBP2

Swiss Prot

Q15366 Human, Q61990 Mouse

Cellular Locus

Cytoplasm, Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Synthetic peptide within human PCBP2 aa 251-300/365.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

Jurkat cell lysate, Hela cell lysate, 293 cell lysate, RAW264.7 cell lysate, human kidney tissue, mouse brain tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500 ;IHC-P: 1:400-1:500

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 39 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes