COASY Recombinant Rabbit Monoclonal Antibody [JE58-56]

About this product

Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA). Alternative splicing results in multiple isoforms. Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation.

Specifications

Catalog number

HA721128

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Bifunctional coenzyme A synthase antibody Bifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinase antibody CoA synthase antibody COASY antibody COASY_HUMAN antibody Coenzyme A synthase antibody Dephospho-CoA kinase antibody Dephospho-CoA pyrophosphorylase antibody Dephosphocoenzyme A kinase antibody DPCK antibody DPCOAK antibody NBP antibody Nucleotide binding protein antibody Pantetheine-phosphate adenylyltransferase antibody Phosphopantetheine adenylyltransferase / dephosphocoenzyme A kinase antibody pOV 2 antibody POV-2 antibody POV2 antibody PPAT antibody UKR1 antibody

Abbreviation

COASY

Swiss Prot

Q13057 Human

Cellular Locus

Mitochondrion matrix, Cytoplasm.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human COASY aa 510-564.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, FC

Positive Control

HepG2 cell lysate, HeLa cell lysate, A431 cell lysate, HepG2.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:2,000 ;FC: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 62 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes