CD16 Recombinant Rabbit Monoclonal Antibody [PD00-12]

About this product

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other responses, including antibody dependent cellular mediated cytotoxicity and antibody dependent enhancement of virus infections. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene are associated with immunodeficiency 20, and have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. CD16 (FcγRIII) is a low affinity Fc receptor that binds to IgG antibodies. Two forms of the receptor, CD16A (FcγRIIIa) and CD16B (FcγRIIIb) are present in natural killer cells, neutrophils, monocytes and activated macrophages. Antibody-dependent cell-mediated cytotoxicity (ADCC), cytokine release and microbe killing can be induced upon binding with CD16. Sconocchia, et al. demonstrated in a recent study that colorectal carcinoma patients with high CD16+ cell infiltration was associated with improved overall survival after adjusting for known prognostic factors and this association was independent from CD8+ lymphocyte infiltration and presence of metastases.

Specifications

Catalog number

HA721149

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

CD 16 antibody CD 16a antibody CD16 antibody CD16a antibody CD16a antigen antibody CD16B antibody CD16b antigen antibody Fc fragment of IgG antibody Fc fragment of IgG low affinity IIIa receptor (CD16) antibody Fc fragment of IgG low affinity IIIa receptor antibody Fc fragment of IgG receptor IIIa antibody Fc fragment of IgG, low affinity III, receptor (CD16) antibody Fc fragment of IgG, low affinity III, receptor for (CD16) antibody Fc fragment of IgG, low affinity IIIa, receptor (CD16) antibody Fc fragment of IgG, low affinity IIIa, receptor (CD16a) antibody Fc fragment of IgG, low affinity IIIa, receptor for antibody Fc fragment of IgG, low affinity IIIb, receptor (CD16b) antibody Fc fragment of IgG, low affinity IIIb, receptor for (CD16) antibody Fc gamma R3 antibody Fc gamma receptor III 2 (CD 16) antibody Fc gamma receptor III A antibody Fc gamma receptor IIIA antibody Fc gamma receptor IIIb (CD 16) antibody Fc gamma RIII alpha antibody Fc gamma RIII antibody Fc gamma RIII beta antibody Fc gamma RIIIa antibody Fc gamma RIIIb antibody Fc of IgG antibody Fc-gamma receptor III2 (CD 16) antibody Fc-gamma receptor III2 (CD16) antibody Fc-gamma receptor IIIb (CD16) antibody Fc-gamma RIII antibody Fc-gamma RIII-alpha antibody Fc-gamma RIIIa antibody FCG 3 antibody FCG3 antibody FCG3A_HUMAN antibody FCgammaRIIIA antibody FCGR 3 antibody FCGR 3A antibody FCGR3 antibody FCGR3A antibody FCGR3A protein antibody FCGRIII antibody FCGRIII-2 antibody FcR 10 antibody FcR-10 antibody FcR10 antibody FcRIII antibody FcRIIIa antibody IGFR 3 antibody IGFR3 antibody IgG Fc receptor III 1 antibody IgG Fc receptor III 2 antibody IgG Fc receptor III-2 antibody IMD20 antibody immunoglobulin G Fc receptor III antibody immunoglobulin G Fc receptor III-2 antibody Low affinity IIIa receptor antibody Low affinity immunoglobulin gamma Fc region receptor III A antibody Low affinity immunoglobulin gamma Fc region receptor III-A antibody Low affinity immunoglobulin gamma Fc region receptor IIIB antibody neutrophil-specific antigen NA antibody

Abbreviation

FCGR3A

Swiss Prot

P08637 Human

Cellular Locus

Cell membrane, Secreted.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within human CD16 aa 17-208 (Extracellular).

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

IHC-P, IF-Tissue, IF-Cell

Positive Control

Human spleen tissue, human liver carcinoma tissue, human muscle tissue, 293T, Jurkat.

Concentration

1 mg/mL

Dilution

IHC-P: 1:1,000 ;IF-Tissue: 1:200 ;IF-Cell: 1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 29 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes