CD22 Recombinant Rabbit Monoclonal Antibody [PO00-31]

Catalog number HA721157

Price for HA721157

Size / count 100 µL

About this product

CD22 antigen appears early in B-cell lymphocyte differentiation at approximately the same stage as the CD19 antigen. Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. CD22 may be a useful marker for phenotyping mature leukemias, as CD22 membrane expression has been shown to be limited to the late differentiation stages between mature B cells (CD22+) and plasma cells (CD22-). CD22 is also strongly expressed in hairy cell leukemia.

Specifications

Catalog number: HA721157
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: B cell receptor CD22 precursor antibody B lymphocyte cell adhesion molecule antibody B-cell receptor CD22 antibody B-lymphocyte cell adhesion molecule antibody BL CAM antibody BL-CAM antibody BLCAM antibody CD 22 antibody CD22 antibody CD22 antigen antibody CD22 molecule antibody CD22 protein antibody CD22_HUMAN antibody Lectin 2 antibody Leu14 antibody Lyb8 antibody MGC130020 antibody sialic acid binding Ig like lectin 2 antibody Sialic acid binding immunoglobulin like lectin 2 antibody Sialic acid-binding Ig-like lectin 2 antibody SIGLEC 2 antibody Siglec-2 antibody SIGLEC2 antibody T cell surface antigen Leu 14 antibody T-cell surface antigen Leu-14 antibody
Abbreviation: CD22
Swiss Prot: P20273 Human
Cellular Locus: Cell membrane.
Host: Rabbit
Species Reactivity: Human
Immunogen: Synthetic peptide within Human CD22 aa 1-100 (N terminal).
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IHC-P
Positive Control: Daudi cell lysates, human B-cell lymphoma tissue, human tonsil tissue, human spleen tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000 ;IHC-P: 1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 95 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for CD22 Recombinant Rabbit Monoclonal Antibody [PO00-31]?

The catalog number for CD22 Recombinant Rabbit Monoclonal Antibody [PO00-31] is HA721157.

What sizes are available for CD22 Recombinant Rabbit Monoclonal Antibody [PO00-31]?

CD22 Recombinant Rabbit Monoclonal Antibody [PO00-31] is available in the following size(s): 100 µL.

Is CD22 Recombinant Rabbit Monoclonal Antibody [PO00-31] in stock?

CD22 Recombinant Rabbit Monoclonal Antibody [PO00-31] is currently made to order / not held in immediate stock. Contact us for lead time.

What is CD22 Recombinant Rabbit Monoclonal Antibody [PO00-31] used for?

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.

Is this antibody conjugated?

Conjugation status, such as unconjugated, HRP, FITC, or biotin, is specified in the product name and confirmed on the datasheet.

What is the sensitivity of this ELISA kit?

Assay sensitivity, including the minimum detectable dose, is listed on the datasheet. Kits that are assembled on order typically ship within 2-4 weeks.