CD47 Recombinant Rabbit Monoclonal Antibody [PD00-33]

About this product

CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα). Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. Furthermore, it plays a key role in immune and angiogenic responses. CD47 is ubiquitously expressed in human cells and has been found to be overexpressed in many different tumor cells. Expression in equine cutaneous tumors has been reported as well.

Specifications

Catalog number

HA721158

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Antigen identified by monoclonal antibody 1D8 antibody Antigenic surface determinant protein OA3 antibody CD 47 antibody CD47 antibody CD47 antigen (Rh-related antigen, integrin-associated signal transducer) antibody CD47 antigen antibody CD47 glycoprotein antibody CD47 molecule antibody CD47_HUMAN antibody IAP antibody Integrin Associated Protein antibody Integrin associated signal transducer antibody Integrin-associated protein antibody Leukocyte surface antigen CD47 antibody MER 6 antibody MER6 antibody OA 3 antibody OA3 antibody OTTHUMP00000041152 antibody OTTHUMP00000041153 antibody Protein MER6 antibody Rh related antigen antibody Surface antigen identified by monoclonal antibody 1D8 antibody

Abbreviation

CD47

Swiss Prot

Q08722 Human

Cellular Locus

Cell membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human CD47 aa 50-150 (internal sequence).

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

IHC-P, FC

Positive Control

Human ovarian tumor tissue, human prostate tissue, Jurkat.

Concentration

1 mg/mL

Dilution

IHC-P: 1:1,000 ;FC: 1:500-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 35 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes