KMT3B Recombinant Rabbit Monoclonal Antibody [1B1]

About this product

This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Specifications

Catalog number

HA721166

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Androgen receptor coactivator 267 kDa protein antibody Androgen receptor-associated protein of 267 kDa antibody ARA267 antibody H3 K36 HMTase antibody H3-K36-HMTase antibody H4 K20 HMTase antibody H4-K20-HMTase antibody Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific antibody KMT3B antibody Lysine N-methyltransferase 3B antibody NR binding SET domain containing protein antibody NR-binding SET domain-containing protein antibody Nsd1 antibody NSD1_HUMAN antibody Nuclear receptor binding SET domain containing protein 1 antibody Nuclear receptor binding SET domain protein 1 antibody Nuclear receptor-binding SET domain-containing protein 1 antibody

Abbreviation

NSD1

Swiss Prot

Q96L73 Human

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within Human KMT3B aa 1-200 / 2,696.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

IF-Cell

Positive Control

293.

Concentration

1 mg/mL

Dilution

IF-Cell: 1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 297 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes