Human IL-6 Recombinant Rabbit Monoclonal Antibody [PS00-21] - BSA and Azide free (Capture)

Catalog number HA721167

Price for HA721167

Size / count 100 µL

About this product

Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. IL-6's role as an anti-inflammatory myokine is mediated through its inhibitory effects on TNF-alpha and IL-1 and its activation of IL-1ra and IL-10. There is some early evidence that IL-6 can be used as an inflammatory marker for severe COVID-19 infection with poor prognosis, in the context of the wider coronavirus pandemic. IL-6 is secreted by macrophages in response to specific microbial molecules, referred to as pathogen-associated molecular patterns (PAMPs). These PAMPs bind to an important group of detection molecules of the innate immune system, called pattern recognition receptors (PRRs), including Toll-like receptors (TLRs). These are present on the cell surface and intracellular compartments and induce intracellular signaling cascades that give rise to inflammatory cytokine production. IL-6 is an important mediator of fever and of the acute phase response. IL-6 stimulates the inflammatory and auto-immune processes in many diseases such as multiple sclerosis, neuromyelitis optica spectrum disorder (NMOSD), diabetes, atherosclerosis, depression, Alzheimer's disease, systemic lupus erythematosus, multiple myeloma, prostate cancer, Behçet's disease, rheumatoid arthritis, and intracerebral hemorrhage. The Detection Antibody (HA721168) supplied in an unconjugated format and it is suitable for sandwich ELISAs to quantify Human IL-6. The recommended pair for sandwich ELISA is Capture Antibody (HA721167). The reference range value is 5 - 1000 pg/ml for human IL-6.

Specifications

Catalog number: HA721167
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: Interleukin BSF 2 antibody B cell differentiation factor antibody B cell stimulatory factor 2 antibody B-cell stimulatory factor 2 antibody BSF 2 antibody BSF-2 antibody BSF2 antibody CDF antibody CTL differentiation factor antibody Cytotoxic T cell differentiation factor antibody Hepatocyte stimulating factor antibody Hepatocyte stimulatory factor antibody HGF antibody HSF antibody Hybridoma growth factor antibody Hybridoma growth factor Interferon beta-2 antibody Hybridoma plasmacytoma growth factor antibody IFN-beta-2 antibody IFNB2 antibody IL 6 antibody IL-6 antibody IL6 antibody IL6_HUMAN antibody Interferon beta 2 antibody Interferon beta-2 antibody Interleukin 6 antibody Interleukin 6 (interferon beta 2) antibody Interleukin BSF 2 antibody Interleukin-6 antibody
Abbreviation: Interleukin-6 IL-6 B-cell stimulatory factor 2 BSF-2 CTL differentiation factor CDF Hybridoma growth factor Interferon beta-2 IFN-beta-2 IL6 IFNB2
Swiss Prot: P05231
Cellular Locus: Extracellular region or secreted.
Host: Rabbit
Species Reactivity: Human
Immunogen: Recombinant full length of human IL6 protein.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: ELISA (Cap)
Positive Control: Recombinant human IL6 protein.
Concentration: 1mg/mL
Dilution: ELISA (Cap): Use at an assay dependent concentration.
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4).
Molecular Weight: Predicted band size: 24 kDa
Storage Conditions: Store at +4°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Human IL-6 Recombinant Rabbit Monoclonal Antibody [PS00-21] - BSA and Azide free (Capture)?

The catalog number for Human IL-6 Recombinant Rabbit Monoclonal Antibody [PS00-21] - BSA and Azide free (Capture) is HA721167.

What sizes are available for Human IL-6 Recombinant Rabbit Monoclonal Antibody [PS00-21] - BSA and Azide free (Capture)?

Human IL-6 Recombinant Rabbit Monoclonal Antibody [PS00-21] - BSA and Azide free (Capture) is available in the following size(s): 100 µL.

Is Human IL-6 Recombinant Rabbit Monoclonal Antibody [PS00-21] - BSA and Azide free (Capture) in stock?

Human IL-6 Recombinant Rabbit Monoclonal Antibody [PS00-21] - BSA and Azide free (Capture) is currently made to order / not held in immediate stock. Contact us for lead time.

What is Human IL-6 Recombinant Rabbit Monoclonal Antibody [PS00-21] - BSA and Azide free (Capture) used for?

Is this antibody conjugated?

Conjugation status, such as unconjugated, HRP, FITC, or biotin, is specified in the product name and confirmed on the datasheet.

What is the sensitivity of this ELISA kit?

Assay sensitivity, including the minimum detectable dose, is listed on the datasheet. Kits that are assembled on order typically ship within 2-4 weeks.

Do you ship this product with dry ice?

Some products, including certain cell lines and biologics, require dry ice for transportation, which carries an additional fee shown clearly in your quotation. Dry ice delivery isn’t always possible to every destination due to transit time or local restrictions, so we check feasibility in advance and you must store the goods at the correct temperature the moment they arrive.