Human IL-6 Recombinant Rabbit Monoclonal Antibody [PS00-15] - BSA and Azide free (Detector)

About this product

Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. IL-6's role as an anti-inflammatory myokine is mediated through its inhibitory effects on TNF-alpha and IL-1 and its activation of IL-1ra and IL-10. There is some early evidence that IL-6 can be used as an inflammatory marker for severe COVID-19 infection with poor prognosis, in the context of the wider coronavirus pandemic. IL-6 is secreted by macrophages in response to specific microbial molecules, referred to as pathogen-associated molecular patterns (PAMPs). These PAMPs bind to an important group of detection molecules of the innate immune system, called pattern recognition receptors (PRRs), including Toll-like receptors (TLRs). These are present on the cell surface and intracellular compartments and induce intracellular signaling cascades that give rise to inflammatory cytokine production. IL-6 is an important mediator of fever and of the acute phase response. IL-6 stimulates the inflammatory and auto-immune processes in many diseases such as multiple sclerosis, neuromyelitis optica spectrum disorder (NMOSD), diabetes, atherosclerosis, depression, Alzheimer's disease, systemic lupus erythematosus, multiple myeloma, prostate cancer, Behçet's disease, rheumatoid arthritis, and intracerebral hemorrhage. The Capture Antibody (HA721167) supplied in an unconjugated format and it is suitable for sandwich ELISAs to quantify Human IL-6. The recommended pair for sandwich ELISA is Detection Antibody (HA721168). The reference range value is 5 - 1000 pg/ml for human IL-6.

Specifications

Catalog number

HA721168

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Interleukin BSF 2 antibody B cell differentiation factor antibody B cell stimulatory factor 2 antibody B-cell stimulatory factor 2 antibody BSF 2 antibody BSF-2 antibody BSF2 antibody CDF antibody CTL differentiation factor antibody Cytotoxic T cell differentiation factor antibody Hepatocyte stimulating factor antibody Hepatocyte stimulatory factor antibody HGF antibody HSF antibody Hybridoma growth factor antibody Hybridoma growth factor Interferon beta-2 antibody Hybridoma plasmacytoma growth factor antibody IFN-beta-2 antibody IFNB2 antibody IL 6 antibody IL-6 antibody IL6 antibody IL6_HUMAN antibody Interferon beta 2 antibody Interferon beta-2 antibody Interleukin 6 antibody Interleukin 6 (interferon beta 2) antibody Interleukin BSF 2 antibody Interleukin-6 antibody

Abbreviation

Interleukin-6 IL-6 B-cell stimulatory factor 2 BSF-2 CTL differentiation factor CDF Hybridoma growth factor Interferon beta-2 IFN-beta-2 IL6 IFNB2

Swiss Prot

P05231 Human

Cellular Locus

Extracellular region or secreted.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant full length of human IL6 protein.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

ELISA (Det)

Positive Control

Recombinant human IL6 protein.

Concentration

1mg/mL

Dilution

ELISA (Det): 1:10,000. Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4).

Molecular Weight

Predicted band size: 24 kDa

Storage Conditions

Store at +4°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes