Calcitonin Recombinant Rabbit Monoclonal Antibody [PD00-46]

About this product

Calcitonin is a 32 amino acid peptide hormone secreted by parafollicular cells (also known as C cells) of the thyroid (or endostyle) in humans and other chordates. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH). It may be used diagnostically as a tumor marker for medullary thyroid cancer, in which high calcitonin levels may be present and elevated levels after surgery may indicate recurrence. It may even be used on biopsy samples from suspicious lesions (e.g., lymph nodes that are swollen) to establish whether they are metastases of the original cancer. Increased levels of calcitonin have also been reported for various other conditions. They include: C-cell hyperplasia, nonthyroidal oat cell carcinoma, nonthyroidal carcinoma and other nonthyroidal malignancies, acute kidney injury and chronic kidney failure, hypercalcemia, hypergastrinemia, and other gastrointestinal disorders, and pulmonary disease. Immunohistochemical staining with anti-calcitonin antibody has proven to be an effective way of demonstrating calcitonin-producing cells in the thyroid. C-cell hyperplasia and medullary thyroid carcinomas stain positive for calcitonin. Studies of calcitonin have resulted in the identification of a wide spectrum of C-cell proliferative abnormalities.

Specifications

Catalog number

HA721181

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Alpha CGRP antibody alpha type CGRP antibody CALC 1 antibody CALC A antibody CALC1 antibody calcitonin 1 antibody calcitonin gene related peptide 1 antibody calcitonin gene related peptide I antibody calcitonin related polypeptide alpha antibody CGRP 1 antibody CGRP antibody CGRP I antibody CGRP1 antibody CT antibody katacalcin antibody KC antibody

Abbreviation

Calcitonin Katacalcin Calcitonin carboxyl-terminal peptide CCP PDN-21 CALCA CALC1

Swiss Prot

P01258 Human

Cellular Locus

Secreted.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within human Calcitonin aa 85-116.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

IHC-P, IF-Cell

Positive Control

Human medullary thyroid carcinoma tissue, human thyroid tissue, TT.

Concentration

1 mg/mL

Dilution

IHC-P: 1:2,000-1:5,000 ;IF-Cell: 1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 15 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes