Phospho-ATR (T1989) Recombinant Rabbit Monoclonal Antibody [PS01-18]

Catalog number HA721190

Price for HA721190

Size / count 100 µL

About this product

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication. Positively regulates the restart of stalled replication forks following activation by the KHDC3L-OOEP scaffold complex.

Specifications

Catalog number: HA721190
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: Ataxia telangiectasia and Rad3 related antibody Ataxia telangiectasia and Rad3-related protein antibody ATR antibody ATR_HUMAN antibody FCTCS antibody FRAP Related Protein 1 antibody FRAP-related protein 1 antibody FRP1 antibody MEC1 antibody MEC1 mitosis entry checkpoint 1 homolog antibody Protein kinase ATR antibody RAC3 antibody Rad3 related protein antibody SCKL antibody SCKL1 antibody Serine/threonine protein kinase ATR antibody Serine/threonine-protein kinase ATR antibody
Abbreviation: ATR, FRP1
Swiss Prot: Q13535 Human
Cellular Locus: Chromosome, Nucleus.
Host: Rabbit
Species Reactivity: Human
Immunogen: Synthetic phosphopeptide corresponding to residues surrounding Thr1989 of human ATR.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IF-Cell
Positive Control: HeLa cell lysate, HeLa treated with Hydroxyurea cell lysate, HeLa treated with 4mM Hydroxyurea for 20 hours.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000 ;IF-Cell: 1:200
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 301 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Phospho-ATR (T1989) Recombinant Rabbit Monoclonal Antibody [PS01-18]?

The catalog number for Phospho-ATR (T1989) Recombinant Rabbit Monoclonal Antibody [PS01-18] is HA721190.

What sizes are available for Phospho-ATR (T1989) Recombinant Rabbit Monoclonal Antibody [PS01-18]?

Phospho-ATR (T1989) Recombinant Rabbit Monoclonal Antibody [PS01-18] is available in the following size(s): 100 µL.

Is Phospho-ATR (T1989) Recombinant Rabbit Monoclonal Antibody [PS01-18] in stock?

Phospho-ATR (T1989) Recombinant Rabbit Monoclonal Antibody [PS01-18] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Phospho-ATR (T1989) Recombinant Rabbit Monoclonal Antibody [PS01-18] used for?

Do you ship this product with dry ice?

Some products, including certain cell lines and biologics, require dry ice for transportation, which carries an additional fee shown clearly in your quotation. Dry ice delivery isn’t always possible to every destination due to transit time or local restrictions, so we check feasibility in advance and you must store the goods at the correct temperature the moment they arrive.

Is this product species cross-reactive?

Cross-reactivity data, based on available testing, is listed under the reactivity section of the datasheet. Contact us if you need reactivity confirmed for a species not listed.

Is there an additional fee for hazardous or dry ice shipping of this product?

Yes, if this product requires dry ice or is classed as hazardous for transport, the additional fee will be explicitly shown in your quotation before you confirm the order, so there are no surprise charges later.