SPARC Recombinant Rabbit Monoclonal Antibody [PD00-57]

About this product

This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca (2+) with a low affinity and an EF-hand loop that binds a Ca (2+) ion with a high affinity.

Specifications

Catalog number

HA721199

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

AA517111 antibody Basement membrane protein 40 antibody Basement-membrane protein 40 antibody BM 40 antibody BM-40 antibody BM40 antibody Cysteine rich protein antibody hm:zeh0062 antibody MGC128090 antibody OI17 antibody ON antibody Osteonectin antibody Secreted acidic cystein rich glycoprotein antibody Secreted protein acidic and cysteine rich antibody Secreted protein acidic and rich in cysteine antibody Secreted protein acidic cysteine rich (osteonectin) antibody Secreted protein acidic cysteine rich antibody SPARC antibody SPRC antibody SPRC_HUMAN antibody

Abbreviation

SPARC

Swiss Prot

P09486 Human

Cellular Locus

Secreted, extracellular space, extracellular matrix, basement membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

IHC-P

Positive Control

Human malignant melanoma tissue, human glioma tissue.

Concentration

1 mg/mL

Dilution

IHC-P: 1:500-1:2,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 35 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes